RUFY1

RUFY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQM, 2YW8
Identifiers
Aliases	RUFY1 , RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDs	OMIM: 610327; MGI: 2429762; HomoloGene: 23522; GeneCards: RUFY1; OMA:RUFY1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 179,550,554 bp [1] End 179,610,012 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 50,280,113 bp [2] End 50,321,952 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon sural nerve corpus callosum ventricular zone blood right uterine tube gastric mucosa granulocyte skin of leg Top expressed in primary oocyte neural layer of retina right kidney granulocyte muscle of thigh zygote transitional epithelium of urinary bladder proximal tubule retinal pigment epithelium secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding lipid binding SH3 domain binding SH2 domain binding Cellular component intracellular membrane-bounded organelle membrane cytoplasm cytosol nuclear speck early endosome membrane endosome nucleus Biological process protein transport endocytosis phosphatidylinositol biosynthetic process regulation of endocytosis small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80230 216724 Ensembl ENSG00000284260 ENSG00000176783 ENSMUSG00000020375 UniProt Q96T51 Q8BIJ7 RefSeq (mRNA) NM_001040451 NM_001040452 NM_025158 NM_172557 RefSeq (protein) NP_001035541 NP_001035542 NP_079434 NP_766145 Location (UCSC) Chr 5: 179.55 – 179.61 Mb Chr 11: 50.28 – 50.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene. ^{[5] [6]} It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX. ^[5]

References

1. ENSG00000176783 GRCh38: Ensembl release 89: ENSG00000284260, ENSG00000176783 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020375 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang J, Kim O, Wu J, Qiu Y (Aug 2002). "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. doi: 10.1074/jbc.M111933200 . PMID   11877430.
6. "Entrez Gene: RUFY1 RUN and FYVE domain containing 1".

Further reading

• Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi: 10.1073/pnas.031586998 . PMC   29309 . PMID   11172003.
• Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC   329268 . PMID   14617813.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.