Ralstonia pickettii

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Ralstonia pickettii
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Phylum: Pseudomonadota
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Ralstonia
Species:
R. pickettii
Binomial name
Ralstonia pickettii
(Ralston et al. 1973)
Yabuuchi et al. 1996
Synonyms

Burkholderia pickettii(Ralston et al. 1973) Yabuuchi et al. 1993 [1]
Pseudomonas pickettiiRalston et al. 1973

Ralstonia pickettii is a Gram-negative, rod-shaped, soil bacterium. [2]

Ralstonia pickettii is a Betaproteobacteria species found in moist environments such as soils, rivers, and lakes. It has also been identified in biofilms in plastic water pipes. It is an oligotrophic organism, making it capable of surviving in areas with a very low concentration of nutrients. Several strains have shown an ability to survive in environments highly contaminated with metals. The ability to persist in these harsh conditions makes R. pickettii a candidate for bioremediation. [3]

Ralstonia pickettii and R. insidiosa are emerging pathogens in hospital settings. [4] R. pickettii pathology does not follow an easy definition. Several hospitals have reported outbreaks—in particular, patients with cystic fibrosis and Crohn's disease have been shown to be infected with R. picketti. Of the 55 reported cases of such infection, the majority are due to contaminated solutions such as water, saline, and sterile drugs. [5] These solutions are usually contaminated when the product is manufactured, because R. pickettii has the ability to pass through 0.45 and 0.2 µm filters that are used to sterilize medicinal products. An outbreak of R. pickettii at a hospital in Queensland, Australia was reported in November 2023, and it is suspected to have caused the death of one patient through contaminated saline.

The majority of R. pickettii and R. insidiosa isolates showed susceptibility to most of the antibiotics tested. [6] The most effective were found to be the quinolones and sulfamethoxazole/trimethoprim. The two bacterial species can be difficult to tell apart. [7] [8]

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Ralstonia is a genus of bacteria, previously included in the genus Pseudomonas. It is named after the American bacteriologist Ericka Ralston. Ericka Ralston was born Ericka Barrett in 1944 in Saratoga, California, and died in 2015 in Sebastopol, California. While in graduate school at the University of California at Berkeley, she identified 20 strains of Pseudomonas which formed a phenotypical homologous group, and named them Pseudomonas pickettii, after M.J. Pickett in the Department of Bacteriology at the University of California at Los Angeles, from whom she had received the strains. Later, P. pickettii was transferred to the new genus Ralstonia, along with several other species. She continued her research into bacterial pathogenesis under the name of Ericka Barrett while a professor of microbiology at the University of California at Davis from 1977 until her retirement in 1996.

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Ralstonia insidiosa is a Gram-negative, environmental bacterium. It has been shown to be a pathogenic in immunocompromised patients in hospital settings. This bacterium is closely related to Ralstonia pickettii.

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References

  1. "Genus Burkholderia". List of Prokaryotic Names with Standing in Nomenclature. Retrieved 15 November 2016.
  2. Yabuuchi, E; Kosako, Y; Yano, I; Hotta, H; Nishiuchi, Y (1995). "Transfer of two Burkholderia and an Alcaligenes species To ralstonia gen. nov.: Proposal of Ralstonia pickettii (Ralston, Palleroni and Doudoroff 1973) comb. Nov., Ralstonia solanacearum (Smith 1896) comb. Nov. And Ralstonia eutropha (Davis 1969) comb. Nov". Microbiology and Immunology. 39 (11): 897–904. doi: 10.1111/j.1348-0421.1995.tb03275.x . PMID   8657018.
  3. Ryan, M.P.; Pembroke, J.T.; Adley, C.C. (October 2007). "Ralstonia pickettii in environmental biotechnology: potential and applications". Journal of Applied Microbiology. 103 (4): 754–764. doi:10.1111/j.1365-2672.2007.03361.x. PMID   17897177. S2CID   23670887.
  4. Ryan, M. P.; Adley, C. C. (March 2014). "Ralstonia spp.: emerging global opportunistic pathogens". European Journal of Clinical Microbiology & Infectious Diseases. 33 (3): 291–304. doi:10.1007/s10096-013-1975-9. ISSN   0934-9723. PMID   24057141. S2CID   254130130.
  5. Ryan, M; Pembroke, J; Adley, C (March 2006). "Ralstonia pickettii: a persistent Gram-negative nosocomial infectious organism". Journal of Hospital Infection. 62 (3): 278–284. doi:10.1016/j.jhin.2005.08.015. PMID   16337309.
  6. Ryan, MP; Adley, CC (Jul 2013). "The antibiotic susceptibility of water-based bacteria Ralstonia pickettii and Ralstonia insidiosa". J Med Microbiol. 62 (7): 1025–31. doi:10.1099/jmm.0.054759-0. PMID   23579396.
  7. Ryan, M. P.; Pembroke, J. T.; Adley, C. C. (2011-10-01). "Differentiating the growing nosocomial infectious threats Ralstonia pickettii and Ralstonia insidiosa". European Journal of Clinical Microbiology & Infectious Diseases. 30 (10): 1245–1247. doi:10.1007/s10096-011-1219-9. ISSN   1435-4373. PMID   21461848. S2CID   10657717.
  8. Ryan, Michael P; Pembroke, J Tony; Adley, Catherine C (2011). "Genotypic and phenotypic diversity of Ralstonia pickettii and Ralstonia insidiosa isolates from clinical and environmental sources including High-purity Water. Diversity in Ralstonia pickettii". BMC Microbiology. 11 (1): 194. doi: 10.1186/1471-2180-11-194 . ISSN   1471-2180. PMC   3175462 . PMID   21878094.