Ralstonia pickettii | |
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Scientific classification | |
Domain: | Bacteria |
Phylum: | Pseudomonadota |
Class: | Betaproteobacteria |
Order: | Burkholderiales |
Family: | Burkholderiaceae |
Genus: | Ralstonia |
Species: | R. pickettii |
Binomial name | |
Ralstonia pickettii (Ralston et al. 1973) Yabuuchi et al. 1996 | |
Synonyms | |
Burkholderia pickettii(Ralston et al. 1973) Yabuuchi et al. 1993 [1] |
Ralstonia pickettii is a Gram-negative, rod-shaped, soil bacterium. [2]
Ralstonia pickettii is a Betaproteobacteria species found in moist environments such as soils, rivers, and lakes. It has also been identified in biofilms in plastic water pipes. It is an oligotrophic organism, making it capable of surviving in areas with a very low concentration of nutrients. Several strains have shown an ability to survive in environments highly contaminated with metals. The ability to persist in these harsh conditions makes R. pickettii a candidate for bioremediation. [3]
Ralstonia pickettii and R. insidiosa are emerging pathogens in hospital settings. [4] R. pickettii pathology does not follow an easy definition. Several hospitals have reported outbreaks—in particular, patients with cystic fibrosis and Crohn's disease have been shown to be infected with R. picketti. Of the 55 reported cases of such infection, the majority are due to contaminated solutions such as water, saline, and sterile drugs. [5] These solutions are usually contaminated when the product is manufactured, because R. pickettii has the ability to pass through 0.45 and 0.2 µm filters that are used to sterilize medicinal products. An outbreak of R. pickettii at a hospital in Queensland, Australia was reported in November 2023, and it is suspected to have caused the death of one patient through contaminated saline.
The majority of R. pickettii and R. insidiosa isolates showed susceptibility to most of the antibiotics tested. [6] The most effective were found to be the quinolones and sulfamethoxazole/trimethoprim. The two bacterial species can be difficult to tell apart. [7] [8]
Pseudomonas is a genus of Gram-negative bacteria belonging to the family Pseudomonadaceae in the class Gammaproteobacteria. The 313 members of the genus demonstrate a great deal of metabolic diversity and consequently are able to colonize a wide range of niches. Their ease of culture in vitro and availability of an increasing number of Pseudomonas strain genome sequences has made the genus an excellent focus for scientific research; the best studied species include P. aeruginosa in its role as an opportunistic human pathogen, the plant pathogen P. syringae, the soil bacterium P. putida, and the plant growth-promoting P. fluorescens, P. lini, P. migulae, and P. graminis.
Bloodstream infections (BSIs) are infections of blood caused by blood-borne pathogens. Blood is normally a sterile environment, so the detection of microbes in the blood is always abnormal. A bloodstream infection is different from sepsis, which is characterized by severe inflammatory or immune responses of the host organism to pathogens.
Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia pseudomallei. Most people exposed to B. pseudomallei experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild, such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. Approximately 10% of people with melioidosis develop symptoms that last longer than two months, termed "chronic melioidosis".
Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative anaerobic, rod-shaped bacterium. It appears as a mucoid lactose fermenter on MacConkey agar.
Staphylococcus lugdunensis is a coagulase-negative member of the genus Staphylococcus, consisting of Gram-positive bacteria with spherical cells that appear in clusters.
Burkholderia cepacia complex (BCC) is a species complex consisting of Burkholderia cepacia and at least 20 different biochemically similar species of Gram-negative bacteria. They are catalase-producing and lactose-nonfermenting. Members of BCC are opportunistic human pathogens that most often cause pneumonia in immunocompromised individuals with underlying lung disease. Patients with sickle-cell haemoglobinopathies are also at risk. The species complex also attacks young onion and tobacco plants, and displays a remarkable ability to digest oil.
Stenotrophomonas maltophilia is an aerobic, nonfermentative, Gram-negative bacterium. It is an uncommon bacterium and human infection is difficult to treat. Initially classified as Bacterium bookeri, then renamed Pseudomonas maltophilia, S. maltophilia was also grouped in the genus Xanthomonas before eventually becoming the type species of the genus Stenotrophomonas in 1993.
Burkholderia pseudomallei is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium. It is a soil-dwelling bacterium endemic in tropical and subtropical regions worldwide, particularly in Thailand and northern Australia. It was reported in 2008 that there had been an expansion of the affected regions due to significant natural disasters, and it could be found in Southern China, Hong Kong, and countries in America. B. pseudomallei, amongst other pathogens, has been found in monkeys imported into the United States from Asia for laboratory use, posing a risk that the pathogen could be introduced into the country.
Elizabethkingia meningoseptica is a Gram-negative, rod-shaped bacterium widely distributed in nature. It may be normally present in fish and frogs; it may be isolated from chronic infectious states, as in the sputum of cystic fibrosis patients. In 1959, American bacteriologist Elizabeth O. King was studying unclassified bacteria associated with pediatric meningitis at the Centers for Disease Control and Prevention in Atlanta, when she isolated an organism that she named Flavobacterium meningosepticum. In 1994, it was reclassified in the genus Chryseobacterium and renamed Chryseobacterium meningosepticum(chryseos = "golden" in Greek, so Chryseobacterium means a golden/yellow rod similar to Flavobacterium). In 2005, a 16S rRNA phylogenetic tree of Chryseobacteria showed that C. meningosepticum along with C. miricola were close to each other but outside the tree of the rest of the Chryseobacteria and were then placed in a new genus Elizabethkingia named after the original discoverer of F. meningosepticum.
Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. It is named after the bacteriologist Paul Baumann. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and is becoming increasingly important as a hospital-derived (nosocomial) infection. While other species of the genus Acinetobacter are often found in soil samples, it is almost exclusively isolated from hospital environments. Although occasionally it has been found in environmental soil and water samples, its natural habitat is still not known.
Burkholderia gladioli is a species of aerobic gram-negative rod-shaped bacteria that causes disease in both humans and plants. It can also live in symbiosis with plants and fungi and is found in soil, water, the rhizosphere, and in many animals. It was formerly known as Pseudomonas marginata.
Ralstonia is a genus of bacteria, previously included in the genus Pseudomonas. It is named after the American bacteriologist Ericka Ralston. Ericka Ralston was born Ericka Barrett in 1944 in Saratoga, California, and died in 2015 in Sebastopol, California. While in graduate school at the University of California at Berkeley, she identified 20 strains of Pseudomonas which formed a phenotypical homologous group, and named them Pseudomonas pickettii, after M.J. Pickett in the Department of Bacteriology at the University of California at Los Angeles, from whom she had received the strains. Later, P. pickettii was transferred to the new genus Ralstonia, along with several other species. She continued her research into bacterial pathogenesis under the name of Ericka Barrett while a professor of microbiology at the University of California at Davis from 1977 until her retirement in 1996.
Sphingomonas paucimobilis is a strictly aerobic Gram-negative bacterium that has a single polar flagellum with slow motility. The cell size is around 0.7 x 1.4 μm. It is usually found in soil. As with the other members of the genus, its biochemistry is remarkable in possession of ubiquinone 10 as its major respiratory quinone, and of glycosphingolipids instead of lipopolysaccharides in its cell envelope. It has been implicated in various types of clinical infections.
Ralstonia mannitolilytica is a Gram-negative soil bacterium. Pseudomonas thomasii and Ralstonia pickettii biovar 3/thomasii are synonyms.
Ralstonia insidiosa is a Gram-negative, environmental bacterium. It has been shown to be a pathogenic in immunocompromised patients in hospital settings. This bacterium is closely related to Ralstonia pickettii.
Pluralibacter gergoviae is a Gram-negative, motile, facultatively-anaerobic, rod-shaped bacterium. P. gergoviae is of special interest to the cosmetics industry, as it displays resistance to parabens, a common antimicrobial agent added to cosmetic products.
Cardiobacterium hominis is a Gram-negative bacillus (rod-shaped) bacterium commonly grouped with other bacteria into the HACEK group. It is one of several bacteria that is normally present in the mouth and upper part of the respiratory tract such as nose and throat. However, it may also rarely cause endocarditis, an infection of the heart valves.
Cupriavidus metallidurans is a non-spore-forming, Gram-negative bacterium which is adapted to survive several forms of heavy metal stress.
Acinetobacter junii is a species of bacteria. Its type strain is ATCC 17908. It can be pathogenic. This bacterium has been linked to nosocomial infections including catheter-related blood stream infections and cellulitis.
Cronobacter malonaticus, formerly considered a subspecies of Cronobacter sakazakii, is a bacterium. Its type strain is CDC 1058-77T.