Replication protein A3

Last updated
RPA3
Protein RPA3 PDB 1l1o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPA3 , REPA3, RP-A p14, replication protein A3
External IDs OMIM: 179837 MGI: 1915490 HomoloGene: 68285 GeneCards: RPA3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002947

NM_026632

RefSeq (protein)

NP_002938

NP_080908

Location (UCSC) Chr 7: 7.64 – 7.72 Mb Chr 6: 8.26 – 8.26 Mb
PubMed search [3] [4]
Wikidata
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Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene. [5] [6]

Contents

Interactions

RPA3 has been shown to interact with replication protein A1 [7] [8] and replication protein A2. [7] [8]

See also

Related Research Articles

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Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks, and works with ATM to ensure genome integrity.

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<span class="mw-page-title-main">Replication protein A1</span> Protein-coding gene in the species Homo sapiens

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

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GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

<span class="mw-page-title-main">Replication protein A</span>

Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination. It also plays roles in responding to damaged DNA.

<span class="mw-page-title-main">RFC1</span> Proteine

Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.

<span class="mw-page-title-main">Cyclin O</span> Protein-coding gene in the species Homo sapiens

Cyclin-O is a protein that in humans is encoded by the CCNO gene.

<span class="mw-page-title-main">RFC4</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

<span class="mw-page-title-main">RFC2</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.

<span class="mw-page-title-main">RFC3</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.

<span class="mw-page-title-main">RFC5</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.

<span class="mw-page-title-main">NFYC</span> Protein-coding gene in the species Homo sapiens

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

<span class="mw-page-title-main">ORC5</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

<span class="mw-page-title-main">EIF3D</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

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DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.

<span class="mw-page-title-main">RPA4</span> Protein-coding gene in the species Homo sapiens

Replication protein A 30 kDa subunit is a protein that in humans is encoded by the RPA4 gene.

<span class="mw-page-title-main">ORC1</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

<span class="mw-page-title-main">Replication protein A2</span> Protein-coding gene in the species Homo sapiens

Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106399 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000012483 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Mar 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". The Journal of Biological Chemistry . 268 (9): 6131–8. doi: 10.1016/S0021-9258(18)53229-4 . PMID   8454588.
  6. "Entrez Gene: RPA3 replication protein A3, 14kDa".
  7. 1 2 Bochkareva E, Frappier L, Edwards AM, Bochkarev A (Feb 1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain". The Journal of Biological Chemistry . 273 (7): 3932–6. doi: 10.1074/jbc.273.7.3932 . PMID   9461578.
  8. 1 2 Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A (Apr 2002). "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA". The EMBO Journal . 21 (7): 1855–63. doi:10.1093/emboj/21.7.1855. PMC   125950 . PMID   11927569.

Further reading