Reticulocalbin 2

RCN2
Identifiers
Aliases	RCN2 , E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2
External IDs	OMIM: 602584 MGI: 1349765 HomoloGene: 2176 GeneCards: RCN2
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.3 Start 76,931,738 bp [1] End 76,954,393 bp [1]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5955	26611
Ensembl	ENSG00000117906	ENSMUSG00000032320
UniProt	Q14257	Q8BP92
RefSeq (mRNA)	NM_002902 NM_001271837	NM_001278274 NM_011992
RefSeq (protein)	NP_001258766 NP_002893	NP_001265203 NP_036122
Location (UCSC)	Chr 15: 76.93 – 76.95 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene. ^{[4] [5] [6]}

Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117906 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Wang JY, Zhen DK, Bianchi DW, Androphy EJ, Chen JJ (Apr 1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33→q24.1 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 60–1. doi:10.1159/000134683. PMID   9533013.
5. Chen JJ, Reid CE, Band V, Androphy EJ (Aug 1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein". Science. 269 (5223): 529–31. Bibcode:1995Sci...269..529C. doi:10.1126/science.7624774. PMID   7624774.
6. "Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi: 10.1074/jbc.M002254200 . PMID   10748068.
• Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi: 10.1074/jbc.272.34.21488 . PMID   9261167.
• Weis K, Griffiths G, Lamond AI (1994). "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif". J. Biol. Chem. 269 (29): 19142–50. doi: 10.1016/S0021-9258(17)32286-X . PMID   8034671.