Rezuforimod

Rezuforimod

Identifiers
IUPAC name 2-{[(2S)-2-[(4-bromophenyl)carbamoylamino]-4-methylpentanoyl]amino}acetic acid
CAS Number	1431754-15-2
PubChem CID	71526099
ChEMBL	ChEMBL4785302
Chemical and physical data
Formula	C15H20BrN3O4
Molar mass	386.246 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C[C@@H](C(=O)NCC(=O)O)NC(=O)NC1=CC=C(C=C1)Br
InChI InChI=1S/C15H20BrN3O4/c1-9(2)7-12(14(22)17-8-13(20)21)19-15(23)18-11-5-3-10(16)4-6-11/h3-6,9,12H,7-8H2,1-2H3,(H,17,22)(H,20,21)(H2,18,19,23)/t12-/m0/s1 Key:LASJSIMHDHTROE-LBPRGKRZSA-N

Rezuforimod is an experimental drug that acts as a potent and selective agonist of formyl peptide receptor 2 with an EC₅₀ of 0.88nM, which inhibits neutrophil adhesion and has antiinflammatory effects. ^{[1] [2]}

References

1. Maciuszek M, Cacace A, Brennan E, Godson C, Chapman TM (March 2021). "Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential". European Journal of Medicinal Chemistry. 213: 113167. doi:10.1016/j.ejmech.2021.113167. PMID   33486199.
2. Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, et al. (March 2021). "Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation". European Journal of Medicinal Chemistry. 214: 113194. doi:10.1016/j.ejmech.2021.113194. PMID   33548634.