Rhodosporidiobolus fluvialis

Rhodosporidiobolus fluvialis
Scientific classification
Domain:	Eukaryota
Kingdom:	Fungi
Division:	Basidiomycota
Class:	Microbotryomycetes
Order:	Sporidiobolales
Family:	Sporidiobolaceae
Genus:	Rhodosporidiobolus
Species:	R. fluvialis
Binomial name
Rhodosporidiobolus fluvialis (Fell, Kurtzman, Tallman & J.D.Buck) Q.M.Wang, F.Y.Bai, M.Groenew. & Boekhout [1]
Synonyms [1]
Rhodosporidium fluvialeFell, Kurtzman, Tallman & J.D. Buck 1988

Rhodosporidiobolus fluvialis is a species of fungus in the family Sporidiobolaceae. It is a human fungal pathogen that exhibits resistance to antifungal compounds like fluconazole and caspofungin. ^[2]

Antifungal resistance

Rhodosporidiobolus fluvialis was isolated from two independent patients. It can proliferate well at 37 °C (99 °F), a temperature similar to the human body's internal temperature. When it is incubated at 37 °C (99 °F), reactive oxygen species accumulate and damage its DNA, which causes mutations that lead to the development of resistance to amphotericin-B. ^[3]

R. fluvialis colonies can be pigmented due to the accumulation of carotenoids in the cells. Carotenoid production has been associated with its resistance to caspofungin. ^[3]

References

1. "Rhodosporidiobolus fluvialis (Fell, Kurtzman, Tallman & J.D.Buck) Q.M.Wang, F.Y.Bai, M.Groenew. & Boekhout". Global Biodiversity Information Facility . Retrieved 17 July 2024.
2. Bowman, Verity. "Are warmer temperatures causing fungi to attack humans? Two deaths in China suggest it may be". The Telegraph.
3. Huang, Jingjing; Hu, Pengjie; Ye, Leixin; Shen, Zhenghao; Chen, Xinfei; Liu, Fang; Xie, Yuyan; Yu, Jinhan; Fan, Xin; Xiao, Meng; Tsui, Clement K. M.; Wang, Weiping; Li, Yingxing; Zhang, Ge; Wong, Koon Ho (July 2024). "Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature" . Nature Microbiology. 9 (7): 1686–1699. doi:10.1038/s41564-024-01720-y. ISSN   2058-5276. PMID   38898217.