Sheffield broke with the PAN in 2018 when he failed to secure the party's nomination for that year's gubernatorial election in Guanajuato. He instead stood as the candidate of a Morena-led coalition but came second to the PAN's Diego SinhuéRodríguez.[5][6]
From 2018 to 2023,he served as director of PROFECO,the federal consumer protection agency. In 2021 he again ran for mayor of León but lost to Alejandra Gutiérrez Campos of the PAN.[5][6]
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