S100A14

S100A14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M0R
Identifiers
Aliases	S100A14 , BCMP84, S100A15, S100 calcium binding protein A14
External IDs	OMIM: 607986 MGI: 1913416 HomoloGene: 10781 GeneCards: S100A14
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,616,986 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,436,144 bp
RNA expression pattern
	Top expressed in
	esophagus; ; cavity of mouth;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding ; chemokine receptor binding ; calcium ion binding ;
Cellular component	cell junction ; perinuclear region of cytoplasm ; extracellular exosome ; cytoplasm ; cytosol ; nuclear body ; plasma membrane ;
Biological process	positive regulation of monocyte chemotaxis ; response to lipopolysaccharide ; calcium ion homeostasis ; apoptotic process ; toll-like receptor 4 signaling pathway ; defense response to bacterium ; positive regulation of granulocyte chemotaxis ;
	Sources:Amigo / QuickGO
Orthologs
	57402
	66166
	ENSG00000189334
	ENSMUSG00000042306
	Q9HCY8
	Q9D2Q8
	NM_020672
	NM_001163525 ; NM_001163526 ; NM_025393
	NP_065723
	NP_001156997 ; NP_001156998 ; NP_079669
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.^[5]

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.^[6]^[7]

Related Research Articles

The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3. They are also considered as damage-associated molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor downregulates the expression of S100 proteins in THP-1 cells.

S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene.

S100 calcium-binding protein A2 (S100A2) is a protein that in humans is encoded by the S100A2 gene and it is located on chromosome 1q21 with other S100 proteins.

Retinoic acid receptor beta (RAR-beta), also known as NR1B2 is a nuclear receptor that in humans is encoded by the RARB gene.

G-protein coupled receptor 31 also known as 12-(S)-HETE receptor is a protein that in humans is encoded by the GPR31 gene. The human gene is located on chromosome 6q27 and encodes a G-protein coupled receptor protein composed of 319 amino acids.

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene. This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG1); two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1). Its encoded protein was later named Retinoic acid-induced protein 3.

S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene.

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.

S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene.

Calpain small subunit 1, also known as CAPN4, is a protein that in humans is encoded by the CAPNS1 gene.

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.

Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene.

Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene.

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.

S100 calcium-binding protein A15 (S100A15), also known as koebnerisin and S100 calcium-binding protein A7A (S100A7A), is a protein that in humans is encoded by the S100A7A (alias:S100A15) gene.

The S100 calcium-binding protein mS100a7a15 is the murine ortholog of human S100A7 (Psoriasin) and human S100A15 (Koebnerisin). mS100a7a15 is also known as S100a15, mS100a7 and mS100a7a and is encoded by the mS100a7a gene

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000189334 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042306 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: S100 calcium binding protein A14".
↑ Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi: 10.3892/or_00000604 . PMID 19956863.
↑ Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi: 10.1158/0008-5472.CAN-08-4231 . PMID 19351828.

Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (Jul 2008). "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". Journal of Immunology. 181 (2): 1499–1506. doi:10.4049/jimmunol.181.2.1499. PMC 2435511 . PMID 18606705.
Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S (Aug 2009). "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients". International Journal of Immunogenetics. 36 (4): 217–22. doi:10.1111/j.1744-313X.2009.00858.x. PMID 19601998. S2CID 38130688.
Jin Q, Chen H, Luo A, Ding F, Liu Z (2011). "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)". PLOS ONE. 6 (4): e19375. Bibcode:2011PLoSO...619375J. doi: 10.1371/journal.pone.0019375 . PMC 3084824 . PMID 21559403.
Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T (Nov 2007). "S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4". The Journal of Investigative Dermatology. 127 (11): 2596–604. doi: 10.1038/sj.jid.5700946 . PMID 17625598.
Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO (Mar 2012). "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest". Oral Oncology. 48 (3): 219–25. doi:10.1016/j.oraloncology.2011.10.001. PMID 22032898.
Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B (May 2006). "Purification, crystallization and preliminary X-ray diffraction of human S100A15". Acta Crystallographica Section F. 62 (Pt 5): 467–470. doi:10.1107/S1744309106012838. PMC 2219979 . PMID 16682778.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000189334 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042306 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S100 calcium binding protein A14".

[6] Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi: 10.3892/or_00000604 . PMID 19956863.

[7] Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi: 10.1158/0008-5472.CAN-08-4231 . PMID 19351828.

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S100A14

Contents

Function

Related Research Articles

References

Further reading