S100A3

S100A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KSO, 3NSI, 3NSK, 3NSL, 3NSO
Identifiers
Aliases	S100A3 , S100E, S100 calcium binding protein A3
External IDs	OMIM: 176992; MGI: 1338849; HomoloGene: 2223; GeneCards: S100A3; OMA:S100A3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,547,329 bp [1] End 153,549,258 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.26 cM Start 90,491,966 bp [2] End 90,510,009 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg skin of abdomen ectocervix upper lobe of left lung canal of the cervix right coronary artery vagina decidua Descending thoracic aorta Top expressed in lip hair follicle corneal stroma embryo morula granulocyte conjunctival fornix skin of back embryo skin of abdomen More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 6274 20197 Ensembl ENSG00000188015 ENSMUSG00000001021 UniProt P33764 P62818 RefSeq (mRNA) NM_002960 NM_011310 NM_001355597 NM_001355600 NM_001355602 RefSeq (protein) NP_002951 NP_035440 NP_001342526 NP_001342529 NP_001342531 Location (UCSC) Chr 1: 153.55 – 153.55 Mb Chr 3: 90.49 – 90.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000188015 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001021 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi: 10.1073/pnas.90.14.6547 . PMC   46969 . PMID   8341667.
6. "Entrez Gene: S100A3 S100 calcium binding protein A3".

Further reading

• Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID   8701470.
• Föhr UG, Heizmann CW, Engelkamp D, et al. (1995). "Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc". J. Biol. Chem. 270 (36): 21056–61. doi: 10.1074/jbc.270.36.21056 . PMID   7673133.
• Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID   7759097.
• Kizawa K, Uchiwa H, Murakami U (1996). "Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle". Biochim. Biophys. Acta. 1312 (2): 94–8. doi:10.1016/0167-4889(96)00023-7. PMID   8672544.
• Böni R, Burg G, Doguoglu A, et al. (1997). "Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions". Br. J. Dermatol. 137 (1): 39–43. doi:10.1111/j.1365-2133.1997.tb03698.x. PMID   9274623.
• Groves P, Finn BE, Kuźnicki J, Forsén S (1998). "A model for target protein binding to calcium-activated S100 dimers". FEBS Lett. 421 (3): 175–9. doi:10.1016/S0014-5793(97)01535-4. PMID   9468301. S2CID   7749285.
• Ridinger K, Ilg EC, Niggli FK, et al. (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta. 1448 (2): 254–63. doi: 10.1016/S0167-4889(98)00137-2 . PMID   9920416.
• Fritz G, Heizmann CW, Kroneck PM (1999). "Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model". Biochim. Biophys. Acta. 1448 (2): 264–76. doi: 10.1016/S0167-4889(98)00138-4 . PMID   9920417.
• Hoyaux D, Decaestecker C, Heizmann CW, et al. (2000). "S100 proteins in Corpora amylacea from normal human brain". Brain Res. 867 (1–2): 280–8. doi:10.1016/S0006-8993(00)02393-3. PMID   10837826. S2CID   7614547.
• Fritz G, Mittl PR, Vasak M, et al. (2002). "The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution". J. Biol. Chem. 277 (36): 33092–8. doi: 10.1074/jbc.M200574200 . PMID   12045193.
• Mittl PR, Fritz G, Sargent DF, et al. (2003). "Metal-free MIRAS phasing: structure of apo-S100A3". Acta Crystallogr. D. 58 (Pt 8): 1255–61. doi:10.1107/S0907444902008430. PMID   12136135.
• Kizawa K, Troxler H, Kleinert P, et al. (2003). "Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles". Biochem. Biophys. Res. Commun. 299 (5): 857–62. doi:10.1016/S0006-291X(02)02744-4. PMID   12470658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.