S100A3

Last updated

S100A3
Protein S100A3 PDB 1kso.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases S100A3 , S100E, S100 calcium binding protein A3
External IDs OMIM: 176992; MGI: 1338849; HomoloGene: 2223; GeneCards: S100A3; OMA:S100A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002960

NM_011310
NM_001355597
NM_001355600
NM_001355602

RefSeq (protein)

NP_002951

NP_035440
NP_001342526
NP_001342529
NP_001342531

Location (UCSC) Chr 1: 153.55 – 153.55 Mb Chr 3: 90.49 – 90.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene. [5] [6]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188015 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001021 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi: 10.1073/pnas.90.14.6547 . PMC   46969 . PMID   8341667.
  6. 1 2 "Entrez Gene: S100A3 S100 calcium binding protein A3".

Further reading