S100A5

Last updated
S100A5
Protein S100A5 PDB 2KAX.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases S100A5 , S100D, S100 calcium binding protein A5
External IDs OMIM: 176991; MGI: 1338915; HomoloGene: 2224; GeneCards: S100A5; OMA:S100A5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002962
NM_001394232
NM_001394233
NM_001394234

NM_011312

RefSeq (protein)

NP_002953

NP_035442

Location (UCSC) Chr 1: 153.54 – 153.54 Mb Chr 3: 90.52 – 90.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A5 (S100A5) is a protein that is encoded by the S100A5 gene in humans. [5] [6]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes, such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196420 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001023 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi: 10.1073/pnas.90.14.6547 . PMC   46969 . PMID   8341667.
  6. 1 2 "Entrez Gene: S100A5 S100 calcium binding protein A5".

Further reading