SAFB2

SAFB2
Identifiers
Aliases	SAFB2 , scaffold attachment factor B2
External IDs	OMIM: 608066 MGI: 2146808 HomoloGene: 35210 GeneCards: SAFB2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,624,046 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,584,585 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; sural nerve; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right adrenal gland; ; nucleus accumbens; ; left uterine tube; ; right lobe of liver;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; thymus; ; lip; ; cerebellar cortex; ; Paneth cell; ; secondary oocyte; ; crypt of lieberkuhn of small intestine; ; lens; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; nucleic acid binding ; identical protein binding ; protein binding ; double-stranded DNA binding ; RNA binding ; sequence-specific DNA binding ;
Cellular component	extracellular exosome ; nucleoplasm ; cytoplasm ; intracellular membrane-bounded organelle ; nucleus ; nuclear body ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; Sertoli cell differentiation ; regulation of transcription by RNA polymerase II ; regulation of androgen receptor signaling pathway ; regulation of mRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	9667
	224902
	ENSG00000130254
	ENSMUSG00000042625
	Q14151
	Q80YR5
	NM_014649
	NM_001029979 ; NM_001355463
	NP_055464
	NP_001025150 ; NP_001342392
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 12, 2024

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.^[5]^[6]

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha ^[5] and SAFB.^[5]

Related Research Articles

Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130254 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042625 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi: 10.1074/jbc.M212988200 . PMID 12660241.
↑ "Entrez Gene: SAFB2 scaffold attachment factor B2".

Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945 . doi: 10.1093/dnares/2.4.167 . PMID 8590280.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130254 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042625 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12660241-5] 1 2 3 Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi: 10.1074/jbc.M212988200 . PMID 12660241.

[entrez-6] "Entrez Gene: SAFB2 scaffold attachment factor B2".

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SAFB2

Contents

Interactions

Related Research Articles

References

Further reading