SAFB2

SAFB2
Identifiers
Aliases	SAFB2 , scaffold attachment factor B2
External IDs	OMIM: 608066; MGI: 2146808; HomoloGene: 35210; GeneCards: SAFB2; OMA:SAFB2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 5,586,999 bp [1] End 5,624,046 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 D Start 56,560,965 bp [2] End 56,584,585 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right uterine tube left ovary right ovary sural nerve canal of the cervix body of uterus right lobe of thyroid gland left lobe of thyroid gland Top expressed in neural layer of retina granulocyte ventricular zone yolk sac superior frontal gyrus tail of embryo thymus lip primary visual cortex muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleic acid binding identical protein binding protein binding double-stranded DNA binding RNA binding sequence-specific DNA binding Cellular component extracellular exosome nucleoplasm cytoplasm intracellular membrane-bounded organelle nucleus nuclear body Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sertoli cell differentiation regulation of transcription by RNA polymerase II regulation of androgen receptor signaling pathway regulation of mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9667 224902 Ensembl ENSG00000130254 ENSMUSG00000042625 UniProt Q14151 Q80YR5 RefSeq (mRNA) NM_014649 NM_001029979 NM_001355463 RefSeq (protein) NP_055464 NP_001025150 NP_001342392 Location (UCSC) Chr 19: 5.59 – 5.62 Mb Chr 17: 56.56 – 56.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene. ^{[5] [6]}

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha ^[5] and SAFB. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000130254 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042625 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi: 10.1074/jbc.M212988200 . PMID   12660241.
6. "Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

• Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID   14587024. S2CID   39178501.
• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX   10.1.1.333.6945 . doi: 10.1093/dnares/2.4.167 . PMID   8590280.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.