SAMD4A

SAMD4A
Identifiers
Aliases	SAMD4A , SAMD4, SMAUG, SMAUG1, SMG, SMGA, sterile alpha motif domain containing 4A
External IDs	OMIM: 610747; MGI: 1921730; HomoloGene: 19167; GeneCards: SAMD4A; OMA:SAMD4A - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q22.2 Start 54,567,097 bp [1] End 54,793,315 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C1 Start 47,120,311 bp [2] End 47,343,272 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve inferior olivary nucleus right ventricle Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii glutes myocardium of left ventricle left testis tail of epididymis Top expressed in seminiferous tubule spermatid tunica media of zone of aorta soleus muscle triceps brachii muscle ankle temporal muscle digastric muscle umbilical cord myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding translation repressor activity mRNA binding RNA binding Cellular component cytoplasm neuron projection dendrite cell projection synapse P-body fibrillar center cytosol cell junction Biological process regulation of translation positive regulation of translation negative regulation of translation nuclear-transcribed mRNA poly(A) tail shortening regulation of mRNA stability regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23034 74480 Ensembl ENSG00000020577 ENSMUSG00000021838 UniProt Q9UPU9 Q8CBY1 RefSeq (mRNA) NM_015589 NM_001161576 NM_001161577 NM_001037221 NM_001163433 NM_028966 NM_001310544 RefSeq (protein) NP_001155048 NP_001155049 NP_056404 NP_001032298 NP_001156905 NP_001297473 NP_083242 Location (UCSC) Chr 14: 54.57 – 54.79 Mb Chr 14: 47.12 – 47.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene. ^[5]

Function

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000020577 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021838 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Sterile alpha motif domain containing 4A" . Retrieved 2020-04-16.

Further reading

• Baez MV, Boccaccio GL (December 2005). "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules". J. Biol. Chem. 280 (52): 43131–40. doi: 10.1074/jbc.M508374200 . hdl: 20.500.12110/paper_00219258_v280_n52_p43131_Baez . PMID   16221671.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC   2945168 . PMID   20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.