SART3

SART3
Identifiers
Aliases	SART3 , DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein
External IDs	OMIM: 611684; MGI: 1858230; GeneCards: SART3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q23.3 Start 108,522,214 bp [1] End 108,561,400 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 113,880,507 bp [2] End 113,910,571 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte tendon of biceps brachii sural nerve Achilles tendon nipple internal globus pallidus cerebellar hemisphere cerebellar vermis epithelium of colon Top expressed in tail of embryo zygote neural layer of retina oocyte primary oocyte secondary oocyte genital tubercle epiblast ventricular zone lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U6atac snRNA binding histone binding U4 snRNA binding protein binding nucleic acid binding ubiquitin-specific protease binding U6 snRNA binding RNA binding Cellular component cytoplasm Cajal body nuclear speck U4/U6 x U5 tri-snRNP complex nucleoplasm U4/U6 snRNP U6atac snRNP U4atac/U6atac snRNP nucleus ASAP complex Biological process mRNA splicing, via spliceosome nucleosome assembly RNA processing spliceosomal tri-snRNP complex assembly homeostasis of number of cells positive regulation of histone deubiquitination hematopoietic stem cell proliferation mRNA processing spliceosomal snRNP assembly cell morphogenesis RNA splicing regulation of gene expression regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9733 53890 Ensembl ENSG00000075856 ENSMUSG00000018974 UniProt Q15020 Q9JLI8 RefSeq (mRNA) NM_014706 NM_016926 NM_001356621 NM_001356623 RefSeq (protein) NP_055521 NP_058622 NP_001343550 NP_001343552 Location (UCSC) Chr 12: 108.52 – 108.56 Mb Chr 5: 113.88 – 113.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene. ^{[5] [6] [7]}

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. ^[7]

Interactions

SART3 has been shown to interact with RNPS1 ^[8] and Androgen receptor. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000075856 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018974 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi: 10.1093/dnares/2.4.167 . PMID   8590280.
6. Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (February 2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Japanese Journal of Cancer Research. 91 (2): 239–47. doi:10.1111/j.1349-7006.2000.tb00937.x. PMC   5926322 . PMID   10761712.
7. "Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3".
8. Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi: 10.1002/ijc.1391 . PMID   11477570. S2CID   24724555.
9. Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi: 10.1074/jbc.M314321200 . PMID   15031286.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K (August 1999). "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients". Cancer Research. 59 (16): 4056–63. PMID   10463607.
• Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K (November 2000). "Expression of tumor-rejection antigens in gynecologic cancers". Japanese Journal of Cancer Research. 91 (11): 1177–84. doi:10.1111/j.1349-7006.2000.tb00902.x. PMC   5926290 . PMID   11092984.
• Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi: 10.1002/ijc.1391 . PMID   11477570. S2CID   24724555.
• Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi: 10.1002/cncr.10421 . PMID   11920522. S2CID   33045822.
• Liu Y, Li J, Kim BO, Pace BS, He JJ (June 2002). "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110". The Journal of Biological Chemistry. 277 (26): 23854–63. doi: 10.1074/jbc.M200773200 . PMID   11959860.
• Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A (June 2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". The EMBO Journal. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMC   126028 . PMID   12032085.
• Nottrott S, Urlaub H, Lührmann R (October 2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". The EMBO Journal. 21 (20): 5527–38. doi:10.1093/emboj/cdf544. PMC   129076 . PMID   12374753.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Stanĕk D, Rader SD, Klingauf M, Neugebauer KM (February 2003). "Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies". The Journal of Cell Biology. 160 (4): 505–16. doi:10.1083/jcb.200210087. PMC   2173746 . PMID   12578909.
• Damianov A, Schreiner S, Bindereif A (February 2004). "Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP". Molecular and Cellular Biology. 24 (4): 1700–8. doi:10.1128/MCB.24.4.1700-1708.2004. PMC   344176 . PMID   14749385.
• Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi: 10.1074/jbc.M314321200 . PMID   15031286.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A (September 2004). "Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling". Molecular and Cellular Biology. 24 (17): 7392–401. doi:10.1128/MCB.24.17.7392-7401.2004. PMC   506986 . PMID   15314151.
• Stanĕk D, Neugebauer KM (September 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". The Journal of Cell Biology. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC   2172029 . PMID   15452143.