SAV1

Last updated

SAV1
Protein SAV1 PDB 2dwv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SAV1 , SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDs OMIM: 607203; MGI: 1927144; HomoloGene: 32517; GeneCards: SAV1; OMA:SAV1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021818

NM_022028

RefSeq (protein)

NP_068590

NP_071311

Location (UCSC) Chr 14: 50.63 – 50.67 Mb Chr 12: 70.01 – 70.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. [5] [6] [7]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000151748 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021067 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): 467–78. doi: 10.1016/S0092-8674(02)00824-3 . PMID   12202036.
  6. Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID   11027580. S2CID   22968498.
  7. 1 2 "SAV1 salvador family WW domain containing protein 1 [ Homo sapiens (human) ]".

Further reading