SBF1

Last updated
SBF1
Protein SBF1 PDB 1v5u.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SBF1 , CMT4B3, DENND7A, MTMR5, SET binding factor 1
External IDs OMIM: 603560 MGI: 1925230 HomoloGene: 84710 GeneCards: SBF1
Orthologs
SpeciesHumanMouse
Entrez

6305

77980

Ensembl

ENSG00000100241

ENSMUSG00000036529

UniProt

O95248

Q6ZPE2

RefSeq (mRNA)

NM_002972
NM_001365819

NM_001081030
NM_001170561
NM_030019

RefSeq (protein)

NP_002963
NP_001352748

NP_001074499
NP_001164032

Location (UCSC) Chr 22: 50.44 – 50.48 Mb Chr 15: 89.17 – 89.2 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene. [5] [6] [7]

Contents

Interactions

SBF1 has been shown to interact with MTMR2 [8] and SUV39H1. [9]

Related Research Articles

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Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.

<span class="mw-page-title-main">SUV39H1</span> Protein-coding gene in the species Homo sapiens

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

<span class="mw-page-title-main">GRAM domain</span> Protein domain

The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins. The structure of the GRAM domain is similar to that found in PH domains.

<span class="mw-page-title-main">Myotubularin 1</span> Protein-coding gene in the species Homo sapiens

Myotubularin is a protein that in humans is encoded by the MTM1 gene.

<span class="mw-page-title-main">PTPN2</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

<span class="mw-page-title-main">MTMR3</span> Protein-coding gene in the species Homo sapiens

Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.

<span class="mw-page-title-main">Myotubularin</span>

Myotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain InterPro: IPR004182. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.

<span class="mw-page-title-main">MTMR6</span> Protein-coding gene in the species Homo sapiens

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.

<span class="mw-page-title-main">PTPRG</span> Protein-coding gene in the species Homo sapiens

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

<span class="mw-page-title-main">PTPRN2</span> Protein-coding gene in the species Homo sapiens

Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in humans is encoded by the PTPRN2 gene. PTPRN and PTPRN2 are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.

<span class="mw-page-title-main">LYL1</span> Protein-coding gene in the species Homo sapiens

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.

<span class="mw-page-title-main">MTMR2</span>

Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene.

<span class="mw-page-title-main">PTPN9</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

<span class="mw-page-title-main">SBF2</span> Protein-coding gene in the species Homo sapiens

Myotubularin-related protein 13 is a protein that in humans is encoded by the SBF2 gene.

<span class="mw-page-title-main">Placental alkaline phosphatase</span> Protein-coding gene in the species Homo sapiens

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.

<span class="mw-page-title-main">MTMR14</span> Protein-coding gene in the species Homo sapiens

Myotubularin related protein 14 also known as MTMR14 is a protein which in humans is encoded by the MTMR14 gene.

<span class="mw-page-title-main">Fig4</span> Protein-coding gene in the species Homo sapiens

Polyphosphoinositide phosphatase also known as phosphatidylinositol 3,5-bisphosphate 5-phosphatase or SAC domain-containing protein 3 (Sac3) is an enzyme that in humans is encoded by the FIG4 gene. Fig4 is an abbreviation for Factor-Induced Gene.

<span class="mw-page-title-main">VAC14</span> Protein-coding gene in the species Homo sapiens

Protein VAC14 homolog, also known as ArPIKfyve, is a protein that in humans is encoded by the VAC14 gene.

<span class="mw-page-title-main">SET domain</span>

The SET domain is a protein domain that typically has methyltransferase activity. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived [Su(var)3-9, Enhancer-of-zeste and Trithorax].

<span class="mw-page-title-main">MTMR12</span> Protein-coding gene in the species Homo sapiens

Myotubularin related protein 12 is a protein that in humans is encoded by the MTMR12 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100241 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036529 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID   9537414. S2CID   25209204.
  6. ↑ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi: 10.1093/hmg/7.11.1703 . PMID   9736772.
  7. ↑ "Entrez Gene: SBF1 SET binding factor 1".
  8. ↑ Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. Bibcode:2003PNAS..100.4492K. doi: 10.1073/pnas.0431052100 . PMC   153583 . PMID   12668758.
  9. ↑ Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC   85941 . PMID   10848615.

Further reading



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