Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Periplakin is a protein that in humans is encoded by the PPL gene.
Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.
Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene.
Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.
Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. It is a member of the Rab family of Ras-related small GTPases.
Nesprin-2 is a protein that in humans is encoded by the SYNE2 gene. The human SYNE2 gene consists of 116 exons and encodes nesprin-2, a member of the nuclear envelope (NE) spectrin-repeat (nesprin) family. Nesprins are modular proteins with a central extended spectrin-repeat (SR) rod domain and a C-terminal Klarsicht/ANC-1/Syne homology (KASH) transmembrane domain, which acts as a NE-targeting motif. Nesprin-2 (Nesp2) binds to cytoplasmic F-actin, tethering the nucleus to the cytoskeleton and maintaining the structural integrity of the nucleus.
Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.
Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.
40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.
Alpha-parvin is a protein that in humans is encoded by the PARVA gene.
Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.
Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.
Protein transport protein Sec61 subunit alpha isoform 1 is a protein that in humans is encoded by the SEC61A1 gene.
Scinderin is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.
Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.
Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.
Vesicular integral-membrane protein VIP36 is a protein that in humans is encoded by the LMAN2 gene.
Secretory carrier-associated membrane protein 5 is a protein that in humans is encoded by the SCAMP5 gene.
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.
