SCAND1

SCAND1
Identifiers
Aliases	SCAND1 , RAZ1, SDP1, SCAN domain containing 1
External IDs	OMIM: 610416; MGI: 1343132; HomoloGene: 10642; GeneCards: SCAND1; OMA:SCAND1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.23 Start 35,953,617 bp [1] End 35,959,472 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 156,153,766 bp [2] End 156,154,667 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon olfactory zone of nasal mucosa right adrenal gland right adrenal cortex left adrenal cortex anterior pituitary right lobe of liver apex of heart right uterine tube gastric mucosa Top expressed in granulocyte tibiofemoral joint seminiferous tubule yolk sac muscle of thigh medial ganglionic eminence calvaria internal carotid artery right kidney external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity protein binding identical protein binding DNA binding Cellular component nucleus Biological process regulation of transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51282 19018 Ensembl ENSG00000171222 ENSMUSG00000046229 UniProt P57086 Q2M4I6 RefSeq (mRNA) NM_033630 NM_016558 NM_001385710 NM_020255 RefSeq (protein) NP_057642 NP_361012 NP_064651 Location (UCSC) Chr 20: 35.95 – 35.96 Mb Chr 2: 156.15 – 156.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene. ^{[5] [6] [7] [8]}

Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene. ^[8]

Interactions

SCAND1 has been shown to interact with MZF1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000171222 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046229 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry. 275 (17): 12857–67. doi: 10.1074/jbc.275.17.12857 . PMID   10777584.
6. Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi: 10.1074/jbc.M000119200 . PMID   10747874.
7. Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC   1223195 . PMID   12444922.
8. "Entrez Gene: SCAND1 SCAN domain containing 1".

Further reading

• Williams AJ, Blacklow SC, Collins T (Dec 1999). "The zinc finger-associated SCAN box is a conserved oligomerization domain". Molecular and Cellular Biology. 19 (12): 8526–35. doi:10.1128/mcb.19.12.8526. PMC   84969 . PMID   10567577.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Sander TL, Morris JF (Aug 2002). "Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization". Gene. 296 (1–2): 53–64. doi:10.1016/S0378-1119(02)00792-8. PMID   12383503.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI (Apr 2006). "Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1". Biochemical and Biophysical Research Communications. 343 (1): 260–8. doi:10.1016/j.bbrc.2006.02.140. PMID   16540086.