MZF1

MZF1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2FI2
Identifiers
Aliases	MZF1 , MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6, myeloid zinc finger 1
External IDs	OMIM: 194550; MGI: 107457; HomoloGene: 9633; GeneCards: MZF1; OMA:MZF1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,573,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,788,691 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right uterine tube; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; pituitary gland; ; left lobe of thyroid gland; ; anterior pituitary; ; right adrenal gland; ; right adrenal cortex; ; left ovary;
	Top expressed in
	male urethra; ; superior frontal gyrus; ; primary visual cortex; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; spermatocyte; ; granulocyte; ; tail of embryo; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific ; protein homodimerization activity ; DNA binding ; protein binding ; nucleic acid binding ; metal ion binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	positive regulation of transcription by RNA polymerase II ; transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	7593
	109889
	ENSG00000099326
	ENSMUSG00000030380
	P28698
	n/a
	NM_001267033 ; NM_003422 ; NM_198055
	NM_001290452 ; NM_001290453 ; NM_145819 ; NM_001382820 ; NM_016793 Contents Interactions ; References ; Further reading ;
	NP_001253962 ; NP_003413 ; NP_932172
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 11, 2024

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.^[5]^[6]

Interactions

MZF1 has been shown to interact with SCAND1.^[7] In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.^[8] The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.^[9]

Related Research Articles

Glyceraldehyde 3-phosphate dehydrogenase is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, ER-to-Golgi vesicle shuttling, and fast axonal, or axoplasmic transport. In sperm, a testis-specific isoenzyme GAPDHS is expressed.

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.

GATA2 or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It regulates many genes that are critical for the embryonic development, self-renewal, maintenance, and functionality of blood-forming, lympathic system-forming, and other tissue-forming stem cells. GATA2 is encoded by the GATA2 gene, a gene which often suffers germline and somatic mutations which lead to a wide range of familial and sporadic diseases, respectively. The gene and its product are targets for the treatment of these diseases.

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene. It is a member of the TIS11 family, along with butyrate response factors 1 and 2.

Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.

Zinc finger and SCAN domain-containing protein 21 is a protein that in humans is encoded by the ZSCAN21 gene.

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099326 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030380 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi: 10.1016/S0021-9258(18)98664-3 . PMID 1860835.
↑ "Entrez Gene: MZF1 myeloid zinc finger 1".
↑ Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi: 10.1074/jbc.275.17.12857 . PMID 10777584.
↑ Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
↑ Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi: 10.1002/jcp.25021 . PMID 25899830. S2CID 6888015.

Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. doi:10.1084/jem.174.5.1097. PMC 2119006 . PMID 1719120.
Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi: 10.1074/jbc.275.17.12857 . PMID 10777584.
Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene. 254 (1–2): 105–118. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781 . PMID 15453830.
Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells. 18 (2): 157–62. doi: 10.1016/S1016-8478(23)13096-2 . PMID 15528990.
Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. doi:10.1016/j.febslet.2004.12.030. PMID 15670815. S2CID 30914046.
Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. doi:10.1016/j.jmb.2006.07.063. PMC 1941711 . PMID 16950398.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000099326 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030380 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1860835-5] Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi: 10.1016/S0021-9258(18)98664-3 . PMID 1860835.

[entrez-6] "Entrez Gene: MZF1 myeloid zinc finger 1".

[pmid10777584-7] Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi: 10.1074/jbc.275.17.12857 . PMID 10777584.

[pmid25065746-8] Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.

[9] Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi: 10.1002/jcp.25021 . PMID 25899830. S2CID 6888015.

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MZF1

Contents

Interactions

Related Research Articles

References

Further reading