SCG3

SCG3
Identifiers
Aliases	SCG3 , SGIII, secretogranin III
External IDs	OMIM: 611796 MGI: 103032 HomoloGene: 7526 GeneCards: SCG3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	51,721,026 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,591,338 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; prefrontal cortex; ; ganglionic eminence; ; amygdala; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; superior frontal gyrus;
	Top expressed in
	islet of Langerhans; ; pontine nuclei; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; cerebellar vermis; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; habenula; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding ;
Cellular component	extracellular region ; secretory granule lumen ; transport vesicle membrane ; membrane ; cytoplasmic vesicle ; endoplasmic reticulum lumen ; secretory granule membrane ; transport vesicle ;
Biological process	platelet degranulation ; post-translational protein modification ; protein localization to secretory granule ;
	Sources:Amigo / QuickGO
Orthologs
	29106
	20255
	ENSG00000104112
	ENSMUSG00000032181
	Q8WXD2
	P47867
	NM_013243 ; NM_001165257
	NM_001164790 ; NM_009130
	NP_001158729 ; NP_037375
	NP_001158262 ; NP_033156
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104112 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032181 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.
1 2 "Entrez Gene: SCG3 secretogranin III".

Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
Ozawa H, Takata K (December 1995). "The granin family--its role in sorting and secretory granule formation". Cell Structure and Function. 20 (6): 415–20. doi: 10.1247/csf.20.415 . PMID 8825061.
Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". Journal of Molecular Neuroscience. 4 (4): 225–33. doi:10.1007/BF02821554. PMID 7917832. S2CID 6030810.
Holthuis JC, Jansen EJ, Martens GJ (July 1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". The Journal of Biological Chemistry. 271 (30): 17755–60. doi: 10.1074/jbc.271.30.17755 . PMID 8663421.
Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Molecular Biology of the Cell. 13 (10): 3388–99. doi:10.1091/mbc.02-03-0040. PMC 129953 . PMID 12388744.
Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T (February 2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". The Journal of Histochemistry and Cytochemistry. 51 (2): 227–38. doi: 10.1177/002215540305100211 . PMID 12533531.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T (January 2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of Biological Chemistry. 279 (5): 3627–34. doi: 10.1074/jbc.M310104200 . PMID 14597614.
Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T (March 2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Archives of Histology and Cytology. 67 (1): 57–64. doi: 10.1679/aohc.67.57 . PMID 15125023.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K (March 2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". The Journal of Clinical Endocrinology and Metabolism. 92 (3): 1145–54. doi: 10.1210/jc.2006-1808 . PMID 17200173.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104112 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032181 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12098761-5] Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.

[entrez-6] 1 2 "Entrez Gene: SCG3 secretogranin III".

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SCG3

Contents

Function

Related Research Articles

References

Further reading