SCO-spondin

SSPOP
Identifiers
Aliases	SSPOP , SCO-spondin, SCO-spondin, pseudogene, SSPO
External IDs	OMIM: 617356; MGI: 2674311; HomoloGene: 45453; GeneCards: SSPOP; OMA:SSPOP - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.1 Start 149,776,042 bp [1] End 149,833,979 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.3 Start 48,425,163 bp [2] End 48,478,184 bp [2]
Gene ontology Molecular function peptidase inhibitor activity Cellular component extracellular region extracellular space Biological process negative regulation of peptidase activity cell adhesion nervous system development cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23145 243369 Ensembl ENSG00000197558 ENSMUSG00000029797 UniProt A2VEC9 Q8CG65 RefSeq (mRNA) NM_198455 NM_173428 RefSeq (protein) NP_940857 NP_775604 Location (UCSC) Chr 7: 149.78 – 149.83 Mb Chr 6: 48.43 – 48.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SCO-spondin is a protein that in humans is encoded by the SSPO gene. ^{[5] [6] [7]} SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000197558 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029797 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID   8743952.
6. Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi: 10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V . PMID   11008217. S2CID   46625717.
7. "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
8. Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID   10197783. S2CID   426154.

Further reading

• Meiniel A, Meiniel R, Gonçalves-Mendes N, Creveaux I, Didier R, Dastugue B (2004). "The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines". International Review of Cytology. 230: 1–39. doi:10.1016/S0074-7696(03)30001-4. PMID   14692680.
• Meiniel O, Meiniel A (February 2007). "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals". Brain Research Reviews. 53 (2): 321–7. doi:10.1016/j.brainresrev.2006.09.007. PMID   17126404. S2CID   7833761.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I, Meiniel A, Guénet JL, Meiniel R (July 2003). "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain". Gene. 312: 263–70. doi:10.1016/S0378-1119(03)00622-X. PMID   12909363.
• Gonçalves-Mendes N, Blanchon L, Meiniel A, Dastugue B, Sapin V (May 2004). "Placental expression of SCO-spondin during mouse and human development". Gene Expression Patterns. 4 (3): 309–14. doi:10.1016/j.modgep.2003.10.004. PMID   15053980.
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.