SCRN1

SCRN1
Identifiers
Aliases	SCRN1 , SES1, secernin 1
External IDs	OMIM: 614965 MGI: 1917188 HomoloGene: 8853 GeneCards: SCRN1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	29,990,289 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	54,543,474 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; cerebellar vermis; ; pons; ; superior vestibular nucleus; ; olfactory bulb; ; spinal ganglia; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; ganglionic eminence;
	Top expressed in
	otolith organ; ; utricle; ; habenula; ; superior cervical ganglion; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; median eminence; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; suprachiasmatic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; dipeptidase activity ; molecular function ;
Cellular component	cytoplasm ; nuclear membrane ; nucleus ;
Biological process	proteolysis ; exocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	9805
	69938
	ENSG00000136193
	ENSMUSG00000019124
	Q12765
	Q9CZC8
	NM_001145513 ; NM_001145514 ; NM_001145515 ; NM_014766
	NM_027268
	NP_001138985 ; NP_001138986 ; NP_001138987 ; NP_055581
	NP_081544
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Secernin-1 is a protein that in humans is encoded by the SCRN1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136193 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019124 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC 124164 . PMID 12221138.
↑ "Entrez Gene: SCRN1 secernin 1".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID 8724849.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
O'Neill EE, Brock CJ, von Kriegsheim AF, et al. (2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID 11921445. S2CID 20643741.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Suda T, Tsunoda T, Uchida N, et al. (2006). "Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray". Cancer Sci. 97 (5): 411–9. doi: 10.1111/j.1349-7006.2006.00194.x . PMID 16630140. S2CID 25739515.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136193 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019124 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12221138-5] Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC 124164 . PMID 12221138.

[entrez-6] "Entrez Gene: SCRN1 secernin 1".

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SCRN1

Related Research Articles

References

Further reading