SCRN1

SCRN1
Identifiers
Aliases	SCRN1 , SES1, secernin 1
External IDs	OMIM: 614965; MGI: 1917188; HomoloGene: 8853; GeneCards: SCRN1; OMA:SCRN1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p14.3 Start 29,920,104 bp [1] End 29,990,289 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B3 Start 54,478,158 bp [2] End 54,543,474 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion cerebellar vermis ventricular zone pons pars reticulata superior vestibular nucleus olfactory bulb pars compacta paraflocculus of cerebellum spinal ganglia Top expressed in otolith organ utricle habenula superior cervical ganglion paraventricular nucleus of hypothalamus dorsal striatum arcuate nucleus median eminence dorsomedial hypothalamic nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding dipeptidase activity molecular function Cellular component cytoplasm nuclear membrane nucleus Biological process proteolysis exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9805 69938 Ensembl ENSG00000136193 ENSMUSG00000019124 UniProt Q12765 Q9CZC8 RefSeq (mRNA) NM_001145513 NM_001145514 NM_001145515 NM_014766 NM_027268 RefSeq (protein) NP_001138985 NP_001138986 NP_001138987 NP_055581 NP_081544 Location (UCSC) Chr 7: 29.92 – 29.99 Mb Chr 6: 54.48 – 54.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Secernin-1 is a protein that in humans is encoded by the SCRN1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000136193 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019124 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC   124164 . PMID   12221138.
6. "Entrez Gene: SCRN1 secernin 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.
• O'Neill EE, Brock CJ, von Kriegsheim AF, et al. (2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID   11921445. S2CID   20643741.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suda T, Tsunoda T, Uchida N, et al. (2006). "Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray". Cancer Sci. 97 (5): 411–9. doi: 10.1111/j.1349-7006.2006.00194.x . PMC   11159625 . PMID   16630140. S2CID   25739515.