SEC14L2

SEC14L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O6U, 1OLM, 4OMJ, 4OMK,%%s1O6U, 1OLM
Identifiers
Aliases	SEC14L2 , C22orf6, SPF, TAP, TAP1, SEC14 like lipid binding 2
External IDs	OMIM: 607558; MGI: 1915065; HomoloGene: 8245; GeneCards: SEC14L2; OMA:SEC14L2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 30,396,941 bp [1] End 30,425,303 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 4,047,039 bp [2] End 4,073,415 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right frontal lobe prefrontal cortex nucleus accumbens amygdala C1 segment cingulate gyrus caudate nucleus putamen anterior cingulate cortex Top expressed in superior surface of tongue left lobe of liver gallbladder olfactory epithelium yolk sac neural layer of retina dentate gyrus of hippocampal formation granule cell jejunum retinal pigment epithelium cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin E binding phospholipid binding lipid binding transporter activity Cellular component cytoplasm integral component of membrane extracellular exosome intracellular anatomical structure nucleus cytosol Biological process regulation of cholesterol biosynthetic process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23541 67815 Ensembl ENSG00000100003 ENSMUSG00000003585 UniProt O76054 Q99J08 RefSeq (mRNA) NM_033382 NM_001204204 NM_001291932 NM_012429 NM_144520 RefSeq (protein) NP_001191133 NP_001278861 NP_036561 NP_203740 NP_036561.1 NP_653103 Location (UCSC) Chr 22: 30.4 – 30.43 Mb Chr 11: 4.05 – 4.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2. ^{[5] [6]}

Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100003 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003585 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
6. "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)".

Further reading

• Caras IW, Friedlander EJ, Bloch K (1980). "Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids". J. Biol. Chem. 255 (8): 3575–80. doi: 10.1016/S0021-9258(19)85740-X . PMID   7364757.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Solheim JC, Harris MR, Kindle CS, Hansen TH (1997). "Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing". J. Immunol. 158 (5): 2236–41. doi: 10.4049/jimmunol.158.5.2236 . PMID   9036970. S2CID   30900833.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
• Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A (2000). "A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization". J. Biol. Chem. 275 (33): 25672–80. doi: 10.1074/jbc.M000851200 . PMID   10829015.
• Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, Inoue K, Arai H (2001). "Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2244–9. Bibcode:2001PNAS...98.2244S. doi: 10.1073/pnas.041620398 . PMC   30123 . PMID   11226224.
• Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi: 10.1093/dnares/8.1.1 . PMID   11258795.
• Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T (2001). "Tocopherol-associated protein is a ligand-dependent transcriptional activator". Biochem. Biophys. Res. Commun. 285 (2): 295–9. doi:10.1006/bbrc.2001.5162. PMID   11444841.
• Stocker A, Tomizaki T, Schulze-Briese C, Baumann U (2003). "Crystal structure of the human supernatant protein factor". Structure. 10 (11): 1533–40. doi: 10.1016/S0969-2126(02)00884-5 . PMID   12429094.
• Singh DK, Mokashi V, Elmore CL, Porter TD (2003). "Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase". J. Biol. Chem. 278 (8): 5646–51. doi: 10.1074/jbc.M211750200 . PMID   12454003.
• Kempná P, Zingg JM, Ricciarelli R, Hierl M, Saxena S, Azzi A (2004). "Cloning of novel human SEC14p-like proteins: ligand binding and functional properties". Free Radic. Biol. Med. 34 (11): 1458–72. doi:10.1016/S0891-5849(03)00173-4. PMID   12757856.
• Stocker A, Baumann U (2003). "Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis". J. Mol. Biol. 332 (4): 759–65. doi:10.1016/S0022-2836(03)00924-0. PMID   12972248.
• Mokashi V, Singh DK, Porter TD (2004). "Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A". Biochem. Biophys. Res. Commun. 316 (3): 688–92. doi:10.1016/j.bbrc.2004.02.103. PMID   15033454.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.