SEC61G

SEC61G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWB, 3J7R, 4CG7, 3J7Q, 4CG5, 4CG6
Identifiers
Aliases	SEC61G , SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma
External IDs	OMIM: 609215; MGI: 1202066; HomoloGene: 40767; GeneCards: SEC61G; OMA:SEC61G - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p11.2 Start 54,752,250 bp [1] End 54,759,974 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A2 Start 16,500,530 bp [2] End 16,508,484 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland body of pancreas anterior pituitary islet of Langerhans mucosa of transverse colon corpus epididymis ganglionic eminence cartilage tissue tendon of biceps brachii ventricular zone Top expressed in epiblast primary oocyte ileum quadriceps femoris muscle embryo jejunum bone marrow embryo neural tube ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-transporting ATPase activity protein binding protein transmembrane transporter activity Cellular component integral component of membrane cytosol endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process protein targeting protein transmembrane transport protein targeting to ER protein transport intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23480 20335 Ensembl ENSG00000132432 ENSMUSG00000078974 UniProt P60059 P60060 RefSeq (mRNA) NM_014302 NM_001012456 NM_001109971 NM_001109972 NM_011343 RefSeq (protein) NP_001012474 NP_055117 NP_001103441 NP_001103442 NP_035473 Location (UCSC) Chr 7: 54.75 – 54.76 Mb Chr 11: 16.5 – 16.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene. ^{[5] [6] [7]}

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000132432 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078974 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID   8107851. S2CID   4323463.
6. Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID   10212142.
7. "Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading

• Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL (December 1996). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. Bibcode:1996Natur.384..432W. doi:10.1038/384432a0. PMID   8945469. S2CID   6276718.
• Chen Y, Le Cahérec F, Chuck SL (May 1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". The Journal of Biological Chemistry. 273 (19): 11887–94. doi: 10.1074/jbc.273.19.11887 . PMID   9565615.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.