SEC63

Last updated
SEC63
Identifiers
Aliases SEC63 , DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator, PCLD2
External IDs OMIM: 608648 MGI: 2155302 HomoloGene: 5220 GeneCards: SEC63
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007214
NM_018529

NM_153055
NM_001359283
NM_001359284
NM_001359285
NM_001359286

Contents

RefSeq (protein)

NP_009145

NP_694695
NP_001346212
NP_001346213
NP_001346214
NP_001346215

Location (UCSC) Chr 6: 107.87 – 107.96 Mb Chr 10: 42.64 – 42.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene. [5] [6] [7]

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [7]

Clinical significance

Mutations of this gene have been linked with autosomal dominant polycystic liver disease. [8]

Related Research Articles

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Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) is an enzyme that in humans is encoded by the ATP2A1 gene.

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<span class="mw-page-title-main">SEC61B</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">DNAJB11</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.

<span class="mw-page-title-main">SEC13</span>

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.

<span class="mw-page-title-main">SSR1</span> Protein-coding gene in the species Homo sapiens

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene.

<span class="mw-page-title-main">SEC31A</span> Protein-coding gene in the species Homo sapiens

Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.

<span class="mw-page-title-main">RRBP1</span> Protein-coding gene in the species Homo sapiens

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Nucleotide exchange factor SIL1 is a protein that in humans is encoded by the SIL1 gene.

<span class="mw-page-title-main">BET1</span> Protein-coding gene in the species Homo sapiens

BET1 homolog is a protein that in humans is encoded by the BET1 gene.

<span class="mw-page-title-main">UBE2J1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">DNAJC10</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TRAM2</span> Protein-coding gene in the species Homo sapiens

Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.

<span class="mw-page-title-main">SEC22A</span> Protein-coding gene in the species Homo sapiens

Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.

<span class="mw-page-title-main">SEC62</span> Protein-coding gene in the species Homo sapiens

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.

<span class="mw-page-title-main">ALG14</span> Protein-coding gene in the species Homo sapiens

UDP-N-acetylglucosamine transferase subunit ALG14 homolog is a protein that in humans is encoded by the ALG14 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000025796 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019802 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Woollatt E, Pine KA, Shine J, Sutherland GR, Iismaa TP (Jun 1999). "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res. 7 (1): 77. doi:10.1023/A:1009283530544. PMID   10219736. S2CID   19417266.
  6. Skowronek MH, Rotter M, Haas IG (Nov 1999). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem. 380 (9): 1133–8. doi:10.1515/BC.1999.142. PMID   10543453. S2CID   46726981.
  7. 1 2 "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)".
  8. Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S (June 2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi: 10.1038/ng1357 . PMID   15133510.

Further reading