SECISBP2

SECISBP2
Identifiers
Aliases	SECISBP2 , SBP2, SECIS binding protein 2
External IDs	OMIM: 607693 MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.2 Start 89,318,500 bp [1] End 89,359,663 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A5 Start 51,651,697 bp [2] End 51,684,044 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mRNA 3'-UTR binding • GO:0001948 protein binding • RNA binding • selenocysteine insertion sequence binding • ribonucleoprotein complex binding Cellular component • nucleus • mitochondrion • ribonucleoprotein complex Biological process • protein biosynthesis • striatum development • neuron development • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • selenocysteine incorporation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79048	75420
Ensembl	ENSG00000187742	ENSMUSG00000035139
UniProt	Q96T21	n/a
RefSeq (mRNA)	NM_001282688 NM_001282689 NM_001282690 NM_024077 NM_001354696 NM_001354697 NM_001354698 NM_001354702	NM_029279 NM_001308448
RefSeq (protein)	NP_001269617 NP_001269618 NP_001269619 NP_076982 NP_001341625 NP_001341626 NP_001341627 NP_001341631	n/a
Location (UCSC)	Chr 9: 89.32 – 89.36 Mb	Chr 13: 51.65 – 51.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene. ^{[5] [6]}

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic. ^[6]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. ^[6]

See also

• Thyroid hormone resistance

References

1. GRCh38: Ensembl release 89: ENSG00000187742 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035139 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM (January 2000). "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs". The EMBO Journal. 19 (2): 306–14. doi:10.1093/emboj/19.2.306. PMC   305564 . PMID   10637234.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Low SC, Grundner-Culemann E, Harney JW, Berry MJ (December 2000). "SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy". The EMBO Journal. 19 (24): 6882–90. doi:10.1093/emboj/19.24.6882. PMC   305907 . PMID   11118223.
• Lescure A, Allmang C, Yamada K, Carbon P, Krol A (May 2002). "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2". Gene. 291 (1–2): 279–85. doi:10.1016/S0378-1119(02)00629-7. PMID   12095701.
• Allmang C, Carbon P, Krol A (October 2002). "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding". RNA. 8 (10): 1308–18. doi:10.1017/S1355838202020034. PMC   1370339 . PMID   12403468.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S (November 2005). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nature Genetics. 37 (11): 1247–52. doi:10.1038/ng1654. PMID   16228000. S2CID   35631638.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Papp LV, Lu J, Striebel F, Kennedy D, Holmgren A, Khanna KK (July 2006). "The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function". Molecular and Cellular Biology. 26 (13): 4895–910. doi:10.1128/MCB.02284-05. PMC   1489162 . PMID   16782878.