Septin-7 is a protein that in humans is encoded by the SEPT7 gene. [5] [6]
Septin-7 is a protein that in humans is encoded by the SEPT7 gene. [5] [6]
This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae . The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms. [6]
SEPT7 has been shown to interact with SEPT2 [7] [8] and SEPT9. [8]
Septins are a group of GTP-binding proteins expressed in all eukaryotic cells except plants. Different septins form protein complexes with each other. These complexes can further assemble into filaments, rings and gauzes. Assembled as such, septins function in cells by localizing other proteins, either by providing a scaffold to which proteins can attach, or by forming a barrier preventing the diffusion of molecules from one compartment of the cell to another, or in the cell cortex as a barrier to the diffusion of membrane-bound proteins.
Cell division control protein 42 homolog is a protein that in humans is encoded by the Cdc42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.
Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.
Septin-9 is a protein that in humans is encoded by the SEPT9 gene.
Septin-5 is a protein that in humans is encoded by the SEPT5 gene.
Septin-4 is a protein that in humans is encoded by the SEPT4 gene.
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.
Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene.
Septin-6 is a protein that in humans is encoded by the SEPT6 gene.
Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ANLN gene in humans and the scraps gene in Drosophila encode Anillin. In 1989, anillin was first isolated in embryos of Drosophila melanogaster. It was identified as an F-actin binding protein. Six years later, the anillin gene was cloned from cDNA originating from a Drosophila ovary. Staining with anti-anillin antibody showed the anillin localizes to the nucleus during interphase and to the contractile ring during cytokinesis. These observations agree with further research that found anillin in high concentrations near the cleavage furrow coinciding with RhoA, a key regulator of contractile ring formation.
60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.
Septin-8 is a protein that in humans is encoded by the SEPT8 gene.
Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.
Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.
G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.
Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.
Septin-11 is a protein that in humans is encoded by the SEPT11 gene.
Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.
Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene. It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.
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