SEPTIN1

SEPTIN1
Identifiers
Aliases	SEPTIN1 , DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDs	OMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 30,378,135 bp [1] End 30,395,991 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,813,619 bp [2] End 126,832,302 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte appendix spleen lymph node thymus blood bone marrow cells mucosa of transverse colon rectum sural nerve Top expressed in granulocyte thymus ventricular zone blood blastocyst morula spleen neural layer of retina lymph node genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding identical protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton microtubule organizing center midbody septin ring synaptic vesicle microtubule cytoskeleton septin complex septin filament array Biological process cell division cell cycle mitotic cytokinesis septin ring assembly regulation of exocytosis cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1731 54204 Ensembl ENSG00000180096 ENSMUSG00000000486 UniProt Q8WYJ6 P42209 RefSeq (mRNA) NM_052838 NM_001365977 NM_017461 RefSeq (protein) NP_443070 NP_001352906 NP_059489 Location (UCSC) Chr 16: 30.38 – 30.4 Mb Chr 7: 126.81 – 126.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene. ^{[5] [6]} It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1. ^[7]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000180096 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000486 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID   8697812.
6. "Entrez Gene: SEPT1 septin 1".
7. Vincent J (6 August 2020). "Scientists rename human genes to stop Microsoft Excel from misreading them as dates". the Verge. Retrieved 2022-10-24.

Further reading

• Nottenburg C, Gallatin WM, St John T (November 1990). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences". Gene. 95 (2): 279–84. doi:10.1016/0378-1119(90)90372-X. PMID   2174398.
• Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC   1853406 . PMID   9811347.
• Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID   12747765.
• Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (October 2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID   16179162.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (November 2007). "Overexpression of Septin1: possible contribution to the development of oral cancer". International Journal of Oncology. 31 (5): 1021–8. doi: 10.3892/ijo.31.5.1021 . PMID   17912427.