SEPW1

SELENOW
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NPB
Identifiers
Aliases	SELENOW , selW, SEPW1, selenoprotein W, 1, selenoprotein W
External IDs	OMIM: 603235; MGI: 1100878; HomoloGene: 2263; GeneCards: SELENOW; OMA:SELENOW - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 47,778,677 bp [1] End 47,784,686 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A2 Start 15,651,133 bp [2] End 15,656,327 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart prefrontal cortex right frontal lobe amygdala hippocampus proper cingulate gyrus caudate nucleus anterior cingulate cortex nucleus accumbens inferior ganglion of vagus nerve Top expressed in saccule supraoptic nucleus triceps brachii muscle temporal lobe otic vesicle globus pallidus prefrontal cortex dentate gyrus aortic valve dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function antioxidant activity Cellular component cytoplasm cytosol Biological process cellular oxidant detoxification response to selenium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6415 20364 Ensembl ENSG00000178980 ENSMUSG00000041571 UniProt P63302 P63300 RefSeq (mRNA) NM_003009 NM_009156 RefSeq (protein) NP_003000 NP_033182 Location (UCSC) Chr 19: 47.78 – 47.78 Mb Chr 7: 15.65 – 15.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene. ^{[5] [6]}

Function

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000178980 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041571 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD (July 1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species". Gene. 193 (2): 187–96. doi:10.1016/S0378-1119(97)00113-3. PMID   9256076.
6. "Entrez Gene: SEPW1 selenoprotein W, 1".

Further reading

• Whanger PD (December 2000). "Selenoprotein W: a review". Cellular and Molecular Life Sciences. 57 (13–14): 1846–52. doi:10.1007/PL00000666. PMC   11147157 . PMID   11215511.
• Yeh JY, Beilstein MA, Andrews JS, Whanger PD (March 1995). "Tissue distribution and influence of selenium status on levels of selenoprotein W". FASEB Journal. 9 (5): 392–6. doi: 10.1096/fasebj.9.5.7896009 . PMID   7896009. S2CID   20754227.
• Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (February 2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID   10708517.
• Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes" . Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID   12775843. S2CID   10363908.
• Bellingham J, Gregory-Evans K, Fox MF, Gregory-Evans CY (June 2003). "Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1627 (2–3): 140–6. doi:10.1016/s0167-4781(03)00078-2. PMID   12818432.
• Pagmantidis V, Bermano G, Villette S, Broom I, Arthur J, Hesketh J (January 2005). "Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon". FEBS Letters. 579 (3): 792–6. Bibcode:2005FEBSL.579..792P. doi: 10.1016/j.febslet.2004.12.042 . PMID   15670848. S2CID   389992.
• Kim YJ, Chai YG, Ryu JC (May 2005). "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion". Biochemical and Biophysical Research Communications. 330 (4): 1095–102. doi:10.1016/j.bbrc.2005.03.080. PMID   15823556.

External links

• Overview of all the structural information available in the PDB for UniProt : P63300 (Mouse Selenoprotein W) at the PDBe-KB .