SERBP1

Not to be confused with srebp1.

SERBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X
Identifiers
Aliases	SERBP1 , CHD3IP, HABP4L, PAI-RBP1, PAIRBP1, CGI-55, SERPINE1 mRNA binding protein 1
External IDs	OMIM: 607378 MGI: 1914120 HomoloGene: 134277 GeneCards: SERBP1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.3 Start 67,407,810 bp [1] End 67,430,415 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 C1 Start 67,215,160 bp [2] End 67,274,720 bp [2]
RNA expression pattern Bgee Top expressed in testicle Achilles tendon endometrium biceps brachii vastus lateralis muscle bone marrow deltoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001948 protein binding mRNA 3'-UTR binding RNA binding cadherin binding SUMO binding Cellular component perinuclear region of cytoplasm plasma membrane extracellular exosome membrane cytosol nucleus cytoplasm Biological process regulation of apoptotic process regulation of mRNA stability PML body organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26135	66870
Ensembl	ENSG00000142864	ENSMUSG00000036371
UniProt	Q8NC51	Q9CY58
RefSeq (mRNA)	NM_015640 NM_001018067 NM_001018068 NM_001018069	NM_001113564 NM_001113565 NM_001113566 NM_025814
RefSeq (protein)	NP_001018077 NP_001018078 NP_001018079 NP_056455	NP_001107036 NP_001107037 NP_001107038 NP_080090
Location (UCSC)	Chr 1: 67.41 – 67.43 Mb	Chr 6: 67.22 – 67.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Plasminogen activator inhibitor 1 RNA-binding protein (serbp1) is a protein that in humans is encoded by the SERBP1 gene. ^{[5] [6] [7]}

Interactions

SERBP1 has been shown to interact with CHD3. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000142864 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036371 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heaton JH, Dlakic WM, Dlakic M, Gelehrter TD (May 2001). "Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA". J Biol Chem. 276 (5): 3341–7. doi: 10.1074/jbc.M006538200 . PMID   11001948.
6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
7. "Entrez Gene: SERBP1 SERPINE1 mRNA binding protein 1".
8. Lemos TA, Passos DO, Nery FC, Kobarg J (Jan 2003). "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Lett. Netherlands. 533 (1–3): 14–20. doi: 10.1016/S0014-5793(02)03737-7 . ISSN   0014-5793. PMID   12505151.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. United States. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . ISSN   0092-8674. PMID   16169070. S2CID   8235923.

Further reading

• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Bucková D; Izakovicová Hollá L; Vácha J (2002). "Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population". Allergy. 57 (5): 446–8. doi:10.1034/j.1398-9995.2002.03582.x. PMID   11972486. S2CID   23925569.
• Jones K, Powell J, Brown L, et al. (2002). "The influence of 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene promoter on the incidence, growth and operative risk of abdominal aortic aneurysm". European Journal of Vascular and Endovascular Surgery. 23 (5): 421–5. doi: 10.1053/ejvs.2002.1633 . PMID   12027469.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lemos TA; Passos DO; Nery FC; Kobarg J (2003). "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Lett. 533 (1–3): 14–20. doi: 10.1016/S0014-5793(02)03737-7 . PMID   12505151.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Lemos TA; Kobarg J (2006). "CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus". Cell Biochem. Biophys. 44 (3): 463–74. doi:10.1385/CBB:44:3:463. PMID   16679534. S2CID   24544907.
• Passos DO; Bressan GC; Nery FC; Kobarg J (2006). "Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation". FEBS J. 273 (17): 3946–61. doi: 10.1111/j.1742-4658.2006.05399.x . PMID   16879614.
• Dalmáz CA, Santos KG, Botton MR, et al. (2006). "Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population". Blood Cells Mol. Dis. 37 (2): 107–10. doi:10.1016/j.bcmd.2006.07.005. PMID   16963292.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Overview of all the structural information available in the PDB for UniProt : Q8NC51 (Plasminogen activator inhibitor 1 RNA-binding protein) at the PDBe-KB .