SERINC1

SERINC1
Identifiers
Aliases	SERINC1 , TDE1L, TDE2, TMS-2, TMS2, serine incorporator 1
External IDs	OMIM: 614548; MGI: 1926228; HomoloGene: 41334; GeneCards: SERINC1; OMA:SERINC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q22.31 Start 122,443,351 bp [1] End 122,471,807 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B4 Start 57,391,870 bp [2] End 57,408,626 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons lateral nuclear group of thalamus orbitofrontal cortex postcentral gyrus pars compacta subthalamic nucleus pars reticulata superior vestibular nucleus external globus pallidus C1 segment Top expressed in lobe of cerebellum cerebellar vermis ventral tegmental area medial dorsal nucleus dorsomedial hypothalamic nucleus dorsal tegmental nucleus medial geniculate nucleus subiculum paraventricular nucleus of hypothalamus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding enzyme binding protein-macromolecule adaptor activity L-serine transmembrane transporter activity Cellular component plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of membrane Biological process phosphatidylserine metabolic process positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity positive regulation of serine C-palmitoyltransferase activity sphingolipid metabolic process phospholipid biosynthetic process lipid metabolism L-serine transport membrane biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57515 56442 Ensembl ENSG00000111897 ENSMUSG00000019877 UniProt Q9NRX5 Q9QZI8 RefSeq (mRNA) NM_020755 NM_019760 RefSeq (protein) NP_065806 NP_062734 Location (UCSC) Chr 6: 122.44 – 122.47 Mb Chr 10: 57.39 – 57.41 Mb PubMed search [3] [4]
Wikidata
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Serine incorporator 1 is a protein that in humans is encoded by the SERINC1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000111897 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019877 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi: 10.1242/jeb.203.3.447 . hdl: 10261/308420 . PMID   10637174.
6. "Entrez Gene: SERINC1 serine incorporator 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.