SFPQ

SFPQ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WII, 4WIJ, 4WIK
Identifiers
Aliases	SFPQ , POMP100, PPP1R140, PSF, splicing factor proline and glutamine rich
External IDs	OMIM: 605199; MGI: 1918764; HomoloGene: 3714; GeneCards: SFPQ; OMA:SFPQ - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.3 Start 35,176,378 bp [1] End 35,193,446 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D2.2|4 61.2 cM Start 127,021,324 bp [2] End 127,037,013 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone ganglionic eminence right uterine tube sural nerve cerebellar hemisphere right hemisphere of cerebellum left ovary right ovary sperm Top expressed in tail of embryo genital tubercle ventricular zone mandibular prominence Rostral migratory stream maxillary prominence epiblast abdominal wall ganglionic eminence neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding histone deacetylase binding chromatin binding transcription cis-regulatory region binding protein binding nucleic acid binding DNA binding protein homodimerization activity RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding Cellular component cytoplasm paraspeckles nuclear matrix RNA polymerase II transcription regulator complex chromatin nucleus nucleoplasm extracellular matrix nuclear speck dendrite cytoplasm Biological process histone H3 deacetylation DNA recombination regulation of transcription, DNA-templated rhythmic process negative regulation of circadian rhythm mRNA processing negative regulation of transcription by RNA polymerase II chromosome organization transcription, DNA-templated cellular response to DNA damage stimulus regulation of cell cycle regulation of circadian rhythm double-strand break repair via homologous recombination RNA splicing positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of sister chromatid cohesion negative regulation of transcription, DNA-templated alternative mRNA splicing, via spliceosome DNA repair positive regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response dendritic transport of messenger ribonucleoprotein complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6421 71514 Ensembl ENSG00000116560 ENSMUSG00000028820 UniProt P23246 Q8VIJ6 RefSeq (mRNA) NM_005066 NM_023603 RefSeq (protein) NP_005057 NP_076092 Location (UCSC) Chr 1: 35.18 – 35.19 Mb Chr 4: 127.02 – 127.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene. ^{[5] [6]}

Interactions

SFPQ has been shown to interact with PTBP1, ^{[5] [7]} NONO, ^[8] CDC5L ^[9] and Ubiquitin C. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000116560 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028820 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (Mar 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development. 7 (3): 393–406. doi: 10.1101/gad.7.3.393 . PMID   8449401.
6. "Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)".
7. Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry. 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID   10653975. S2CID   25669908.
8. Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG (Oct 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC   1370341 . PMID   12403470.
9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
10. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.

Further reading

• Shav-Tal Y, Zipori D (Nov 2002). "PSF and p54(nrb)/NonO--multi-functional nuclear proteins". FEBS Letters. 531 (2): 109–14. doi: 10.1016/S0014-5793(02)03447-6 . PMID   12417296. S2CID   12485304.
• Gower HJ, Moore SE, Dickson G, Elsom VL, Nayak R, Walsh FS (Apr 1989). "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody". Development. 105 (4): 723–31. doi:10.1242/dev.105.4.723. PMID   2480877.
• Gozani O, Patton JG, Reed R (Jul 1994). "A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction". The EMBO Journal. 13 (14): 3356–67. doi:10.1002/j.1460-2075.1994.tb06638.x. PMC   395233 . PMID   8045264.
• Zhang WW, Zhang LX, Busch RK, Farrés J, Busch H (Feb 1993). "Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells". The Biochemical Journal. 290 (1): 267–72. doi:10.1042/bj2900267. PMC   1132410 . PMID   8439294.
• Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS (Oct 1997). "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma". Oncogene. 15 (18): 2233–9. CiteSeerX   10.1.1.462.8435 . doi: 10.1038/sj.onc.1201394 . PMID   9393982.
• Teigelkamp S, Mundt C, Achsel T, Will CL, Lührmann R (Nov 1997). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p". RNA. 3 (11): 1313–26. PMC   1369570 . PMID   9409622.
• Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F (Oct 1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". The Journal of Biological Chemistry. 273 (41): 26261–4. doi: 10.1074/jbc.273.41.26261 . PMID   9756848.
• Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC (Dec 1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC   1369720 . PMID   9848648.
• Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (Jan 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". Journal of Cellular Biochemistry. 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID   10653975. S2CID   25669908.
• Urban RJ, Bodenburg Y, Kurosky A, Wood TG, Gasic S (Jun 2000). "Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element". Molecular Endocrinology. 14 (6): 774–82. doi: 10.1210/mend.14.6.0485 . PMID   10847580.
• Straub T, Knudsen BR, Boege F (Jun 2000). "PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices". Biochemistry. 39 (25): 7552–8. doi:10.1021/bi992898e. PMID   10858305.
• Akhmedov AT, Lopez BS (Aug 2000). "Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion". Nucleic Acids Research. 28 (16): 3022–30. doi:10.1093/nar/28.16.3022. PMC   108454 . PMID   10931916.
• de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (Nov 2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". The EMBO Journal. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC   305781 . PMID   11060040.
• Dye BT, Patton JG (Feb 2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles". Experimental Cell Research. 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID   11161712.
• Mathur M, Tucker PW, Samuels HH (Apr 2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and Cellular Biology. 21 (7): 2298–311. doi:10.1128/MCB.21.7.2298-2311.2001. PMC   86864 . PMID   11259580.
• Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J, Zipori D (Aug 2001). "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions". Molecular Biology of the Cell. 12 (8): 2328–40. doi:10.1091/mbc.12.8.2328. PMC   58597 . PMID   11514619.
• Zhang Z, Carmichael GG (Aug 2001). "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs". Cell. 106 (4): 465–75. doi: 10.1016/S0092-8674(01)00466-4 . PMID   11525732. S2CID   18799711.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR (Apr 2002). "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription". Endocrinology. 143 (4): 1280–90. doi: 10.1210/endo.143.4.8748 . PMID   11897684.