SFRP2

SFRP2
Identifiers
Aliases	SFRP2 , FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDs	OMIM: 604157 MGI: 108078 HomoloGene: 56438 GeneCards: SFRP2
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.3 Start 153,780,591 bp [1] End 153,789,083 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 E3|3 37.37 cM Start 83,673,628 bp [2] End 83,681,623 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura gallbladder vena cava trachea lactiferous duct pericardium visceral pleura gastric mucosa vulva saphenous vein Top expressed in ascending aorta aortic valve calvaria hand endocardial cushion renal corpuscle condyle fossa internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding receptor ligand activity endopeptidase activator activity integrin binding enzyme activator activity G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component extracellular matrix extracellular region extracellular space integral component of membrane collagen-containing extracellular matrix Biological process cellular response to extracellular stimulus positive regulation of endopeptidase activity Wnt signaling pathway involved in somitogenesis somitogenesis cell differentiation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process male gonad development regulation of establishment of planar polarity response to nutrient collagen fibril organization convergent extension involved in axis elongation development of primary male sexual characteristics positive regulation of canonical Wnt signaling pathway negative regulation of mesodermal cell fate specification cellular response to X-ray cell-cell signaling negative regulation of Wnt signaling pathway bone morphogenesis hematopoietic stem cell proliferation chondrocyte development embryonic digit morphogenesis outflow tract morphogenesis cardiac left ventricle morphogenesis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Wnt signaling pathway negative regulation of gene expression sclerotome development positive regulation of peptidyl-serine phosphorylation positive regulation of angiogenesis planar cell polarity pathway involved in neural tube closure negative regulation of BMP signaling pathway multicellular organism development negative regulation of cardiac muscle cell apoptotic process regulation of apoptotic process positive regulation of cell growth neural tube closure negative regulation of peptidyl-tyrosine phosphorylation negative regulation of cell migration positive regulation of osteoblast differentiation regulation of Wnt signaling pathway cartilage development regulation of cell population proliferation regulation of stem cell division negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of cell growth neural tube development positive regulation of cell population proliferation negative regulation of epithelial cell proliferation positive regulation of apoptotic process branching involved in blood vessel morphogenesis post-anal tail morphogenesis negative regulation of dermatome development negative regulation of planar cell polarity pathway involved in axis elongation positive regulation of cell adhesion mediated by integrin negative regulation of transcription, DNA-templated negative regulation of JUN kinase activity positive regulation of fat cell differentiation negative regulation of epithelial to mesenchymal transition negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II digestive tract morphogenesis anterior/posterior pattern specification apoptotic process negative regulation of canonical Wnt signaling pathway regulation of midbrain dopaminergic neuron differentiation regulation of neuron projection development G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6423 20319 Ensembl ENSG00000145423 ENSMUSG00000027996 UniProt Q96HF1 P97299 RefSeq (mRNA) NM_003013 NM_009144 RefSeq (protein) NP_003004 NP_033170 Location (UCSC) Chr 4: 153.78 – 153.79 Mb Chr 3: 83.67 – 83.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. ^{[5] [6]} This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. ^[6]

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury .

Cancer

SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. ^[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000145423 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027996 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi: 10.1073/pnas.94.25.13636 . PMC   28358 . PMID   9391078.
6. "Entrez Gene: SFRP2 secreted frizzled-related protein 2".
7. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl: 11392/2066612 . PMID   25205602. S2CID   24986454.

Further reading

• Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. Bibcode:1997PNAS...94.2859R. doi: 10.1073/pnas.94.7.2859 . PMC   20287 . PMID   9096311.
• Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93. doi:10.1006/bbrc.1998.8784. PMID   9642118.
• Lescher B, Haenig B, Kispert A (1999). "sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney". Dev. Dyn. 213 (4): 440–51. doi: 10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6 . PMID   9853965.
• Chang JT, Esumi N, Moore K, et al. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium". Hum. Mol. Genet. 8 (4): 575–83. doi: 10.1093/hmg/8.4.575 . PMID   10072424.
• Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. doi:10.1242/dev.127.1.109. PMID   10654605.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Brophy PD, Lang KM, Dressler GR (2004). "The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor". J. Biol. Chem. 278 (52): 52401–5. doi: 10.1074/jbc.M305614200 . PMID   14561758.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lee JL, Lin CT, Chueh LL, Chang CJ (2004). "Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis". J. Biol. Chem. 279 (15): 14602–9. doi: 10.1074/jbc.M309008200 . PMID   14709558.
• Müller HM, Oberwalder M, Fiegl H, et al. (2004). "Methylation changes in faecal DNA: a marker for colorectal cancer screening?". Lancet. 363 (9417): 1283–5. doi:10.1016/S0140-6736(04)16002-9. PMID   15094274. S2CID   22608605.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Clément G, Braunschweig R, Pasquier N, et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus". Oncogene. 25 (21): 3084–92. doi: 10.1038/sj.onc.1209338 . PMID   16407829.
• Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi: 10.1158/1078-0432.CCR-05-2468 . PMID   16609023.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Huang ZH, Li LH, Yang F, Wang JF (2007). "Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions". World J. Gastroenterol. 13 (6): 950–4. doi: 10.3748/wjg.v13.i6.950 . PMC   4065936 . PMID   17352030.
• Veeck J, Noetzel E, Bektas N, Jost E, Hartmann A, Knuchel R, Dahl E (2008). "Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer". Mol Cancer. 7 (83): 83. doi: 10.1186/1476-4598-7-83 . PMC   2613402 . PMID   18990230.