SFRS12

SREK1
Identifiers
Aliases	SREK1 , SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDs	OMIM: 609268 MGI: 2145245 HomoloGene: 10581 GeneCards: SREK1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	66,183,615 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	103,774,608 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding ; • nucleic acid binding ; • RNA binding ;
Cellular component	• spliceosomal complex ; • cell nucleus ; • nucleoplasm ; • nuclear speck ;
Biological process	• mRNA processing ; • RNA splicing ; • regulation of alternative mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	140890
	218543
	ENSG00000153914
	ENSMUSG00000032621
	Q8WXA9
	Q8BZX4
NM_001077199 ; NM_001270492 ; NM_001270493 ; NM_139168 ; NM_001323527 ;
	NM_001323529 ; NM_001323533 ; NM_001323534 ; NM_001323535
	NM_172592 ; NM_001361085
NP_001070667 ; NP_001257421 ; NP_001310456 ; NP_001310458 ; NP_001310462 ;
	NP_001310463 ; NP_001310464 ; NP_631907
	NP_766180 ; NP_001348014
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 20, 2020

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.^[5]^[6]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[6]

Related Research Articles

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene.

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.

Splicing factor, arginine/serine-rich 16 is a protein that in humans is encoded by the SFRS16 gene.

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153914 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032621 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.
1 2 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940. S2CID 21158144.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616 . PMID 14559993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341 . PMID 12403470.
Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor". J. Biol. Chem. 277 (42): 39485–92. doi: 10.1074/jbc.M201784200 . PMID 12183448.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633 . PMID 12176931.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273 . PMID 11991645.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584 . PMID 10757789.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153914 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032621 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12043562-5] Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.

[entrez-6] 1 2 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

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SFRS12

Related Research Articles

References

Further reading