SFRS12

SREK1
Identifiers
Aliases	SREK1 , SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDs	OMIM: 609268; MGI: 2145245; HomoloGene: 10581; GeneCards: SREK1; OMA:SREK1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q12.3 Start 66,139,971 bp [1] End 66,183,615 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D1 Start 103,875,856 bp [2] End 103,911,116 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon right uterine tube corpus epididymis ventricular zone caput epididymis body of pancreas left lobe of thyroid gland right lobe of thyroid gland body of uterus Top expressed in genital tubercle tail of embryo Rostral migratory stream neural layer of retina yolk sac zygote pineal gland medullary collecting duct ventricular zone lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component spliceosomal complex nucleus nucleoplasm nuclear speck Biological process mRNA processing RNA splicing regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140890 218543 Ensembl ENSG00000153914 ENSMUSG00000032621 UniProt Q8WXA9 Q8BZX4 RefSeq (mRNA) NM_001077199 NM_001270492 NM_001270493 NM_139168 NM_001323527 NM_001323529 NM_001323533 NM_001323534 NM_001323535 NM_172592 NM_001361085 RefSeq (protein) NP_001070667 NP_001257421 NP_001310456 NP_001310458 NP_001310462 NP_001310463 NP_001310464 NP_631907 NP_766180 NP_001348014 Location (UCSC) Chr 5: 66.14 – 66.18 Mb Chr 13: 103.88 – 103.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene. ^{[5] [6]}

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000153914 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032621 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID   12043562.
6. "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID   15456940. S2CID   21158144.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC   1370341 . PMID   12403470.
• Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor". J. Biol. Chem. 277 (42): 39485–92. doi: 10.1074/jbc.M201784200 . PMID   12183448.
• Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC   186633 . PMID   12176931.
• Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC   1370273 . PMID   11991645.
• Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC   85584 . PMID   10757789.