SFRS3

SRSF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I38
Identifiers
Aliases	SRSF3 , SFRS3, SRp20, serine/arginine-rich splicing factor 3, serine and arginine rich splicing factor 3
External IDs	OMIM: 603364; MGI: 98285; HomoloGene: 55708; GeneCards: SRSF3; OMA:SRSF3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.31-p21.2 Start 36,594,353 bp [1] End 36,605,600 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 15.03 cM Start 29,251,602 bp [2] End 29,262,347 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence monocyte pericardium thymus mucosa of sigmoid colon vena cava lymph node epithelium of nasopharynx amniotic fluid Top expressed in genital tubercle ventricular zone tail of embryo medial ganglionic eminence primitive streak abdominal wall embryo embryo neural tube mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding sequence-specific mRNA binding protein binding RNA binding Cellular component nucleus cytoplasm nucleoplasm nuclear speck Biological process termination of RNA polymerase II transcription mRNA 3'-end processing mRNA splicing, via spliceosome mRNA export from nucleus mRNA transport mRNA processing RNA splicing regulation of mRNA splicing, via spliceosome RNA export from nucleus transport regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6428 20383 Ensembl ENSG00000112081 ENSMUSG00000071172 UniProt P84103 P84104 RefSeq (mRNA) NM_003017 NM_013663 RefSeq (protein) NP_003008 NP_038691 Location (UCSC) Chr 6: 36.59 – 36.61 Mb Chr 17: 29.25 – 29.26 Mb PubMed search [3] [4]
Wikidata
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Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene. ^{[5] [6]}

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UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112081 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071172 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi: 10.1101/gad.6.5.837 . PMID   1577277.
6. "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
7. Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN   0196-3635. PMID   12634307.

Further reading

• Ayane M; Preuss U; Köhler G; Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC   333853 . PMID   2030943.
• Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID   8208298. S2CID   4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
• Cáceres JF; Screaton GR; Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC   316398 . PMID   9420331.
• Zhang WJ; Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC   108778 . PMID   9447963.
• Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC   310739 . PMID   9647638.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC   148514 . PMID   10390541.
• Barnard DC; Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC   85584 . PMID   10757789.
• Shnyreva M, Schullery DS, Suzuki H, et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem. 275 (20): 15498–503. doi: 10.1074/jbc.275.20.15498 . PMID   10809782.
• Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi: 10.1073/pnas.97.11.5717 . PMC   18499 . PMID   10823932.
• Huang Y; Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA". Mol. Cell. 7 (4): 899–905. doi: 10.1016/S1097-2765(01)00233-7 . PMID   11336712.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Barnard DC; Li J; Peng R; Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC   1370273 . PMID   11991645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Guo TB, Boros LG, Chan KC, et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID   12634307.
• Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID   12890497.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). J. Biol. Chem. 279 (34): 35788–97. doi: 10.1074/jbc.M403927200 . PMID   15169763. S2CID   39752996.
• Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.