SH2B2

SH2B2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q2H
Identifiers
Aliases	SH2B2 , APS, SH2B adaptor protein 2
External IDs	OMIM: 605300 MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	102,321,711 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,275,410 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; vastus lateralis muscle; ; renal medulla; ; thoracic diaphragm; ; tibialis anterior muscle; ; body of tongue; ; ventral tegmental area; ; pylorus; ; cardia; ; gastrocnemius muscle;
	Top expressed in
	brown adipose tissue; ; white adipose tissue; ; spermatocyte; ; ganglionic eminence; ; internal carotid artery; ; placenta; ; subcutaneous adipose tissue; ; intercostal muscle; ; medial ganglionic eminence; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	JAK pathway signal transduction adaptor activity ; protein binding ; signaling adaptor activity ; transmembrane receptor protein tyrosine kinase adaptor activity ; identical protein binding ;
Cellular component	cytoplasm ; cytosol ; plasma membrane ; membrane ; stress fiber ; ruffle ; actin filament ;
Biological process	insulin receptor signaling pathway ; blood coagulation ; signal transduction ; regulation of receptor signaling pathway via JAK-STAT ; positive regulation of signal transduction ; intracellular signal transduction ; B-1 B cell homeostasis ; nervous system development ; cytokine-mediated signaling pathway ; regulation of metabolic process ; actin cytoskeleton organization ; regulation of Ras protein signal transduction ; regulation of immune response ; antigen receptor-mediated signaling pathway ; brown fat cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	10603
	23921
	ENSG00000160999
	ENSMUSG00000005057
	O14492
	Q9JID9
	NM_020979 ; NM_001359228 ; NM_001359229 ; NM_001359230 ; NM_001359231 Contents Function ; Interactions ; References ; Further reading ;
	NM_018825 ; NM_001302938 ; NM_001302939
	NP_066189 ; NP_001346157 ; NP_001346158 ; NP_001346159 ; NP_001346160
	NP_001289867 ; NP_001289868 ; NP_061295
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.^[5]^[6]

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.^[6]

Interactions

SH2B2 has been shown to interact with TrkA ^[7] and Cbl gene.^[8]^[9]

Related Research Articles

<span class="mw-page-title-main">GRB2</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is a member of the TEC family of kinases and is highly expressed in T cells.

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene.

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160999 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005057 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi: 10.1038/sj.onc.1201163 . PMID 9233773.
1 2 "Entrez Gene: SH2B2 SH2B adaptor protein 2".
↑ Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi: 10.1016/S0896-6273(00)80620-0 . PMID 9856458. S2CID 12354383.
↑ Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi: 10.1038/sj/leu/2401397 . PMID 10374881.
↑ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755 . PMID 18273061.

Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788 . PMID 9799793.
Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi: 10.1016/S0896-6273(00)80620-0 . PMID 9856458. S2CID 12354383.
Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A (1999). "APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis". Oncogene. 18 (3): 759–67. doi: 10.1038/sj.onc.1202326 . PMID 9989826.
Moodie SA, Alleman-Sposeto J, Gustafson TA (1999). "Identification of the APS protein as a novel insulin receptor substrate". J. Biol. Chem. 274 (16): 11186–93. doi: 10.1074/jbc.274.16.11186 . PMID 10196204.
Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi: 10.1038/sj/leu/2401397 . PMID 10374881.
Iseki M, Takaki S, Takatsu K (2000). "Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins". Biochem. Biophys. Res. Commun. 272 (1): 45–54. doi:10.1006/bbrc.2000.2736. PMID 10872802.
O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases". J. Biol. Chem. 277 (10): 8673–81. doi: 10.1074/jbc.M109165200 . PMID 11751854.
Liu J, Kimura A, Baumann CA, Saltiel AR (2002). "APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes". Mol. Cell. Biol. 22 (11): 3599–609. doi:10.1128/MCB.22.11.3599-3609.2002. PMC 133825 . PMID 11997497.
Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–9. doi: 10.1038/sj.onc.1205927 . PMID 12400014.
Ahn MY, Katsanakis KD, Bheda F, Pillay TS (2004). "Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling". J. Biol. Chem. 279 (20): 21526–32. doi: 10.1074/jbc.M307740200 . PMID 15031295.
Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex". J. Biol. Chem. 279 (37): 38881–8. doi: 10.1074/jbc.M406101200 . PMID 15231829.
Hu J, Hubbard SR (2005). "Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins". J. Biol. Chem. 280 (19): 18943–9. doi: 10.1074/jbc.M414157200 . PMID 15737992.
Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S (2005). "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation". Biochem. Biophys. Res. Commun. 330 (3): 1005–13. doi:10.1016/j.bbrc.2005.03.073. PMID 15809095.
Katsanakis KD, Pillay TS (2006). "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588". J. Biol. Chem. 280 (45): 37827–32. doi: 10.1074/jbc.M505959200 . PMID 16141217.
Li M, Li Z, Morris DL, Rui L (2007). "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling". Endocrinology. 148 (4): 1615–21. doi:10.1210/en.2006-1010. PMC 4710543 . PMID 17204555.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160999 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005057 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9233773-5] Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi: 10.1038/sj.onc.1201163 . PMID 9233773.

[entrez-6] 1 2 "Entrez Gene: SH2B2 SH2B adaptor protein 2".

[pmid9856458-7] Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi: 10.1016/S0896-6273(00)80620-0 . PMID 9856458. S2CID 12354383.

[pmid10374881-8] Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi: 10.1038/sj/leu/2401397 . PMID 10374881.

[pmid18273061-9] Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755 . PMID 18273061.

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SH2B2

Contents

Function

Interactions

Related Research Articles

References

Further reading