SH2B2

SH2B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q2H
Identifiers
Aliases	SH2B2 , APS, SH2B adaptor protein 2
External IDs	OMIM: 605300; MGI: 1345171; HomoloGene: 10309; GeneCards: SH2B2; OMA:SH2B2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 102,285,091 bp [1] End 102,321,711 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 136,247,001 bp [2] End 136,275,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in triceps brachii muscle Skeletal muscle tissue of biceps brachii muscle of thigh vastus lateralis muscle renal medulla muscle of trunk Skeletal muscle tissue of rectus abdominis thoracic diaphragm tibialis anterior muscle body of tongue Top expressed in brown adipose tissue granulocyte white adipose tissue tunica adventitia of aorta spermatocyte ganglionic eminence internal carotid artery gastrula tail of embryo placenta More reference expression data BioGPS n/a
Gene ontology Molecular function JAK pathway signal transduction adaptor activity protein binding signaling adaptor activity transmembrane receptor protein tyrosine kinase adaptor activity identical protein binding Cellular component cytoplasm cytosol plasma membrane membrane stress fiber ruffle actin filament Biological process insulin receptor signaling pathway blood coagulation signal transduction regulation of receptor signaling pathway via JAK-STAT positive regulation of signal transduction intracellular signal transduction B-1 B cell homeostasis nervous system development cytokine-mediated signaling pathway regulation of metabolic process actin cytoskeleton organization regulation of Ras protein signal transduction regulation of immune response antigen receptor-mediated signaling pathway brown fat cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10603 23921 Ensembl ENSG00000160999 ENSMUSG00000005057 UniProt O14492 Q9JID9 RefSeq (mRNA) NM_020979 NM_001359228 NM_001359229 NM_001359230 NM_001359231 NM_018825 NM_001302938 NM_001302939 RefSeq (protein) NP_066189 NP_001346157 NP_001346158 NP_001346159 NP_001346160 NP_001289867 NP_001289868 NP_061295 Location (UCSC) Chr 7: 102.29 – 102.32 Mb Chr 5: 136.25 – 136.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene. ^{[5] [6]}

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2. ^[6]

Interactions

SH2B2 has been shown to interact with TrkA ^[7] and Cbl gene. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000160999 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005057 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi: 10.1038/sj.onc.1201163 . PMID   9233773.
6. "Entrez Gene: SH2B2 SH2B adaptor protein 2".
7. Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi: 10.1016/S0896-6273(00)80620-0 . PMID   9856458. S2CID   12354383.
8. Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi: 10.1038/sj/leu/2401397 . PMID   10374881.
9. Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC   2265755 . PMID   18273061.

Further reading

• Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC   310788 . PMID   9799793.
• Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi: 10.1016/S0896-6273(00)80620-0 . PMID   9856458. S2CID   12354383.
• Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A (1999). "APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis". Oncogene. 18 (3): 759–67. doi: 10.1038/sj.onc.1202326 . PMID   9989826.
• Moodie SA, Alleman-Sposeto J, Gustafson TA (1999). "Identification of the APS protein as a novel insulin receptor substrate". J. Biol. Chem. 274 (16): 11186–93. doi: 10.1074/jbc.274.16.11186 . PMID   10196204.
• Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi: 10.1038/sj/leu/2401397 . PMID   10374881.
• Iseki M, Takaki S, Takatsu K (2000). "Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins". Biochem. Biophys. Res. Commun. 272 (1): 45–54. doi:10.1006/bbrc.2000.2736. PMID   10872802.
• O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases". J. Biol. Chem. 277 (10): 8673–81. doi: 10.1074/jbc.M109165200 . PMID   11751854.
• Liu J, Kimura A, Baumann CA, Saltiel AR (2002). "APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes". Mol. Cell. Biol. 22 (11): 3599–609. doi:10.1128/MCB.22.11.3599-3609.2002. PMC   133825 . PMID   11997497.
• Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–9. doi: 10.1038/sj.onc.1205927 . PMID   12400014.
• Ahn MY, Katsanakis KD, Bheda F, Pillay TS (2004). "Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling". J. Biol. Chem. 279 (20): 21526–32. doi: 10.1074/jbc.M307740200 . PMID   15031295.
• Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex". J. Biol. Chem. 279 (37): 38881–8. doi: 10.1074/jbc.M406101200 . PMID   15231829.
• Hu J, Hubbard SR (2005). "Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins". J. Biol. Chem. 280 (19): 18943–9. doi: 10.1074/jbc.M414157200 . PMID   15737992.
• Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S (2005). "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation". Biochem. Biophys. Res. Commun. 330 (3): 1005–13. doi:10.1016/j.bbrc.2005.03.073. PMID   15809095.
• Katsanakis KD, Pillay TS (2006). "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588". J. Biol. Chem. 280 (45): 37827–32. doi: 10.1074/jbc.M505959200 . PMID   16141217.
• Li M, Li Z, Morris DL, Rui L (2007). "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling". Endocrinology. 148 (4): 1615–21. doi:10.1210/en.2006-1010. PMC   4710543 . PMID   17204555.