SH3GLB2

SH3GLB2
Identifiers
Aliases	SH3GLB2 , PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like endophilin B2, SH3 domain containing GRB2 like, endophilin B2
External IDs	OMIM: 609288; MGI: 2385131; HomoloGene: 10595; GeneCards: SH3GLB2; OMA:SH3GLB2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.11 Start 129,007,036 bp [1] End 129,028,331 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 30,234,821 bp [2] End 30,249,349 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary C1 segment right frontal lobe skin of abdomen skin of leg anterior cingulate cortex right hemisphere of cerebellum prefrontal cortex body of stomach right uterine tube Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex interventricular septum transitional epithelium of urinary bladder lip neural layer of retina central gray substance of midbrain esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding cadherin binding Cellular component cytoplasm nucleoplasm cytosol Biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56904 227700 Ensembl ENSG00000148341 ENSMUSG00000026860 UniProt Q9NR46 Q8R3V5 RefSeq (mRNA) NM_001287045 NM_001287046 NM_020145 NM_001369913 NM_001369914 NM_001369915 NM_001289709 NM_001289710 NM_139302 NM_001346806 NM_001362888 RefSeq (protein) NP_001273974 NP_001273975 NP_064530 NP_001356842 NP_001356843 NP_001356844 NP_001276638 NP_001276639 NP_001333735 NP_647463 NP_001349817 Location (UCSC) Chr 9: 129.01 – 129.03 Mb Chr 2: 30.23 – 30.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene. ^{[5] [6]}

Interactions

SH3GLB2 has been shown to interact with SH3GLB1 ^[5] and SH3KBP1. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000148341 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026860 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID   11161816.
6. "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".
7. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. Bibcode:2002Natur.416..187P. doi:10.1038/416187a. PMID   11894096. S2CID   4389099.
8. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature . 416 (6877): 183–7. Bibcode:2002Natur.416..183S. doi:10.1038/416183a. PMID   11894095. S2CID   635702.

Further reading

• Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC   207616 . PMID   14559993.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mikula M, Dzwonek A, Karczmarski J, Rubel T, Dadlez M, Wyrwicz LS, Bomsztyk K, Ostrowski J (2006). "Landscape of the hnRNP K protein-protein interactome". Proteomics. 6 (8): 2395–406. doi:10.1002/pmic.200500632. PMID   16518874. S2CID   24395284.