SHCBP1

SHCBP1
Identifiers
Aliases	SHCBP1 , PAL, SHC binding and spindle associated 1
External IDs	OMIM: 611027; MGI: 1338802; HomoloGene: 32123; GeneCards: SHCBP1; OMA:SHCBP1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q11.2 Start 46,578,591 bp [1] End 46,621,379 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 4,785,976 bp [2] End 4,829,567 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone bone marrow gonad ganglionic eminence trabecular bone stromal cell of endometrium bone marrow cells appendix testicle Top expressed in otic placode otic vesicle saccule primitive streak maxillary prominence mandibular prominence abdominal wall condyle vas deferens dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH2 domain binding protein binding Cellular component cytoskeleton cytoplasm spindle midbody Biological process regulation of neural precursor cell proliferation fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79801 20419 Ensembl ENSG00000171241 ENSMUSG00000022322 UniProt Q8NEM2 Q9Z179 RefSeq (mRNA) NM_024745 NM_001324318 NM_001324319 NM_011369 RefSeq (protein) NP_001311247 NP_001311248 NP_079021 NP_035499 Location (UCSC) Chr 16: 46.58 – 46.62 Mb Chr 8: 4.79 – 4.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene. ^{[5] [6]}

Interactions

SHCBP1 has been shown to interact with SHC1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000171241 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022322 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schmandt R, Liu SK, McGlade CJ (Mar 1999). "Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells". Oncogene. 18 (10): 1867–1879. doi:10.1038/sj.onc.1202507. PMID   10086341. S2CID   21481825.
6. "Entrez Gene: SHCBP1 SHC SH2-domain binding protein 1".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.