SIPA1L1

SIPA1L1
Identifiers
Aliases	SIPA1L1 , E6TP1, signal induced proliferation associated 1 like 1, SPAR1
External IDs	OMIM: 617504; MGI: 2443679; HomoloGene: 9189; GeneCards: SIPA1L1; OMA:SIPA1L1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.2 Start 71,320,449 bp [1] End 71,741,229 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 D1 Start 82,216,094 bp [2] End 82,498,560 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens testicle external globus pallidus caudate nucleus Region I of hippocampus proper right frontal lobe right hemisphere of cerebellum sural nerve popliteal artery tibial arteries Top expressed in olfactory tubercle temporal lobe nucleus accumbens primary motor cortex prefrontal cortex amygdala lateral septal nucleus Region I of hippocampus proper piriform cortex vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity ephrin receptor binding molecular function Cellular component cytoplasm postsynaptic membrane membrane postsynaptic density plasma membrane dendritic spine synapse cell junction neuron projection cytoskeleton cellular component Biological process actin cytoskeleton reorganization activation of GTPase activity regulation of GTPase activity ephrin receptor signaling pathway regulation of synaptic plasticity regulation of dendrite morphogenesis regulation of axonogenesis regulation of small GTPase mediated signal transduction regulation of dendritic spine morphogenesis biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26037 217692 Ensembl ENSG00000197555 ENSMUSG00000042700 UniProt O43166 Q8C0T5 RefSeq (mRNA) NM_001284245 NM_001284246 NM_001284247 NM_015556 NM_001354285 NM_001354286 NM_001354287 NM_001354288 NM_001354289 NM_001386936 NM_001167983 NM_172579 RefSeq (protein) NP_001271174 NP_001271175 NP_001271176 NP_056371 NP_001341214 NP_001341215 NP_001341216 NP_001341217 NP_001341218 NP_001161455 NP_766167 NP_001394331 NP_001394332 NP_001394333 NP_001394334 NP_001394335 NP_001394336 NP_001394337 NP_001394338 NP_001394339 NP_001394340 NP_001394341 NP_001394342 NP_001394343 NP_001394344 Location (UCSC) Chr 14: 71.32 – 71.74 Mb Chr 12: 82.22 – 82.5 Mb PubMed search [3] [4]
Wikidata
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Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000197555 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042700 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (January 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Molecular and Cellular Biology. 19 (1): 733–44. doi:10.1128/mcb.19.1.733. PMC   83930 . PMID   9858596.
6. "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Lee C, Wooldridge TR, Laimins LA (February 2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology. 358 (1): 201–10. doi: 10.1016/j.virol.2006.08.028 . PMID   16999984.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (December 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi: 10.1016/j.exphem.2004.08.014 . PMID   15588942.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (August 2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron. 31 (2): 289–303. doi: 10.1016/S0896-6273(01)00355-5 . PMID   11502259.
• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.