SKAP2

SKAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OMH
Identifiers
Aliases	SKAP2 , PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2
External IDs	OMIM: 605215 MGI: 1889206 HomoloGene: 2919 GeneCards: SKAP2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	26,995,239 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	51,989,529 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; pericardium; ; monocyte; ; spongy bone; ; visceral pleura; ; bone marrow cells; ; lower lobe of lung; ; pylorus; ; blood;
	Top expressed in
	secondary oocyte; ; blood; ; primitive streak; ; ascending aorta; ; renal corpuscle; ; spleen; ; right lung; ; right lung lobe; ; somite; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	plasma membrane ; cytoplasm ; nucleoplasm ; cytosol ;
Biological process	immune response-activating signal transduction ; B cell activation ; signal transduction ; negative regulation of cell population proliferation ; positive regulation of signal transduction ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	8935
	54353
	ENSG00000005020
	ENSMUSG00000059182
	O75563
	Q3UND0
	NM_003930 ; NM_001303468
	NM_018773
	NP_001290397 ; NP_003921
	NP_061243
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 19, 2024

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.^[7] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.^[8]

Related Research Articles

<span class="mw-page-title-main">GRB2</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

ZAP-70 is a protein normally expressed near the surface membrane of lymphocytes. It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Lymphocyte cytosolic protein 2, also known as LCP2 or SLP-76, is a signal-transducing adaptor protein expressed in T cells and myeloid cells and is important in the signaling of T-cell receptors (TCRs). As an adaptor protein, SLP-76 does not have catalytic functions, primarily binding other signaling proteins to form larger signaling complexes. It is a key component of the signaling pathways of receptors with immunoreceptor tyrosine-based activation motifs (ITAMs) such as T-cell receptors, its precursors, and receptors for the Fc regions of certain antibodies. SLP-76 is expressed in T-cells and related lymphocytes like natural killer cells.

The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene. PKC-θ, a member of serine/threonine kinases, is mainly expressed in hematopoietic cells with high levels in platelets and T lymphocytes, where plays a role in signal transduction. Different subpopulations of T cells vary in their requirements of PKC-θ, therefore PKC-θ is considered as a potential target for inhibitors in the context of immunotherapy.

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.

Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1(SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. SHIP1 is expressed predominantly by hematopoietic cells but also, for example, by osteoblasts and endothelial cells. This phosphatase is important for the regulation of cellular activation. Not only catalytic but also adaptor activities of this protein are involved in this process. Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds. Insufficient regulation of SHIP1 leads to different pathologies.

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

Cytoplasmic protein NCK2 is a protein that in humans is encoded by the NCK2 gene.

FYN binding protein (FYB-120/130), also known as FYB, ADAP, and SLAP-130 is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.

Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000005020 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059182 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
↑ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi: 10.1016/S0014-5793(98)01040-0 . PMID 9755858. S2CID 37288744.
1 2 "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".
↑ Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMC 3561861 . PMID 22976304.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (July 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi: 10.1073/pnas.95.15.8779 . PMC 21153 . PMID 9671755.
Wang X, Stollar BD (November 1999). "Immunoglobulin VH gene expression in human aging". Clinical Immunology. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP (October 2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". The Journal of Biological Chemistry. 275 (43): 33427–34. doi: 10.1074/jbc.M001439200 . PMID 10942756.
Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG (November 2000). "Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest". Experimental Hematology. 28 (11): 1250–9. doi: 10.1016/S0301-472X(00)00537-3 . PMID 11063873.
Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cavé-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (June 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". The Journal of Biological Chemistry. 276 (25): 22375–81. doi: 10.1074/jbc.M011683200 . PMID 11301322.
Kirchgessner H, Dietrich J, Scherer J, Isomäki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B (June 2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". The Journal of Experimental Medicine. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385 . PMID 11390434.
Takahashi T, Yamashita H, Nagano Y, Nakamura T, Ohmori H, Avraham H, Avraham S, Yasuda M, Matsumoto M (October 2003). "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation". The Journal of Biological Chemistry. 278 (43): 42225–33. doi: 10.1074/jbc.M213217200 . PMID 12893833.
Park SY, Avraham HK, Avraham S (August 2004). "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner". The Journal of Biological Chemistry. 279 (32): 33315–22. doi: 10.1074/jbc.M313527200 . PMID 15166227.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000005020 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059182 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9837776-5] Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (November 1998). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.

[pmid9755858-6] Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (September 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Letters. 435 (1): 55–60. doi: 10.1016/S0014-5793(98)01040-0 . PMID 9755858. S2CID 37288744.

[entrez-7] 1 2 "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".

[8] Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD (November 2012). "Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement". Journal of Cell Science. 125 (Pt 22): 5535–45. doi:10.1242/jcs.111260. PMC 3561861 . PMID 22976304.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

SKAP2

Contents

Function

Related Research Articles

References

Further reading