SLIT2

SLIT2
Available structures PDB Ortholog search: H0Y9Z6 PDBe H0Y9Z6 RCSB List of PDB id codes 2V70, 2V9S, 2V9T, 2WFH
Identifiers
Aliases	SLIT2 , SLIL3, Slit-2, slit guidance ligand 2
External IDs	OMIM: 603746; MGI: 1315205; HomoloGene: 3516; GeneCards: SLIT2; OMA:SLIT2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.31 Start 20,251,905 bp [1] End 20,620,561 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B3 Start 48,140,480 bp [2] End 48,465,075 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung olfactory bulb vena cava trigeminal ganglion right lung spinal ganglia urethra pericardium parietal pleura middle temporal gyrus Top expressed in floor plate ciliary body sciatic nerve vas deferens Epithelium of choroid plexus body of femur iris left lung lobe medullary collecting duct mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding heparin binding protein homodimerization activity GTPase inhibitor activity laminin-1 binding protein binding identical protein binding Roundabout binding proteoglycan binding Cellular component cytoplasm membrane extracellular region cell surface extracellular exosome plasma membrane extracellular space Biological process negative regulation of protein phosphorylation negative regulation of chemokine-mediated signaling pathway negative regulation of neutrophil chemotaxis negative regulation of cellular response to growth factor stimulus chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration cell differentiation ureteric bud development negative chemotaxis negative regulation of actin filament polymerization negative regulation of small GTPase mediated signal transduction negative regulation of retinal ganglion cell axon guidance negative regulation of mononuclear cell migration corticospinal neuron axon guidance through spinal cord negative regulation of smooth muscle cell migration Roundabout signaling pathway positive regulation of axonogenesis nervous system development cell migration involved in sprouting angiogenesis negative regulation of endothelial cell migration axon guidance multicellular organism development chemotaxis negative regulation of smooth muscle cell chemotaxis cellular response to hormone stimulus negative regulation of cell migration negative regulation of monocyte chemotaxis negative regulation of cell growth response to cortisol apoptotic process involved in luteolysis positive regulation of apoptotic process induction of negative chemotaxis cellular response to heparin motor neuron axon guidance branching morphogenesis of an epithelial tube negative regulation of leukocyte chemotaxis chemorepulsion involved in postnatal olfactory bulb interneuron migration axon extension involved in axon guidance negative regulation of lamellipodium assembly negative regulation of vascular permeability retinal ganglion cell axon guidance negative regulation of GTPase activity aortic valve morphogenesis pulmonary valve morphogenesis ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9353 20563 Ensembl ENSG00000145147 ENSMUSG00000031558 UniProt O94813 Q9R1B9 RefSeq (mRNA) NM_001289135 NM_001289136 NM_004787 NM_001291227 NM_001291228 NM_178804 RefSeq (protein) NP_001276064 NP_001276065 NP_004778 NP_001278156 NP_001278157 NP_848919 Location (UCSC) Chr 4: 20.25 – 20.62 Mb Chr 5: 48.14 – 48.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene. ^{[5] [6] [7]}

Interactions

SLIT2 has been shown to interact with Glypican 1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000145147 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031558 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Itoh A, Miyabayashi T, Ohno M, Sakano S (February 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID   9813312.
6. Chedotal A (February 2008). "Slits and Their Receptors". Axon Growth and Guidance. Advances in Experimental Medicine and Biology. Vol. 621. pp. 65–80. doi:10.1007/978-0-387-76715-4_5. ISBN   978-0-387-76714-7. PMID   18269211.
7. "Entrez Gene: SLIT2 slit homolog 2 (Drosophila)".
8. Ronca F, Andersen J S, Paech V, Margolis R U (August 2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31). United States: 29141–7. doi: 10.1074/jbc.M100240200 . ISSN   0021-9258. PMID   11375980.

Further reading

• Wong K, Park HT, Wu JY, Rao Y (2003). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Curr. Opin. Genet. Dev. 12 (5): 583–91. doi:10.1016/S0959-437X(02)00343-X. PMID   12200164.
• Zhao XC, Zhang LM, Li Q, Tong DY, Fan LC, An P, Wu XY, Chen WM, Zhao P, Wang J. (2013). "Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1". Brain Res. 1537: 283–9. doi:10.1016/j.brainres.2013.08.036. PMC   3820100 . PMID   23994690.
• Wang KH, Brose K, Arnott D, et al. (1999). "Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching". Cell. 96 (6): 771–84. doi: 10.1016/S0092-8674(00)80588-7 . PMID   10102266. S2CID   16810644.
• Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi: 10.1016/S0092-8674(00)80590-5 . PMID   10102268. S2CID   16301178.
• Li HS, Chen JH, Wu W, et al. (1999). "Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons". Cell. 96 (6): 807–18. doi: 10.1016/S0092-8674(00)80591-7 . PMID   10102269.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–73. doi: 10.1016/S0896-6273(00)80702-3 . PMID   10197527. S2CID   18663762.
• Holmes GP, Negus K, Burridge L, et al. (1999). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mech. Dev. 79 (1–2): 57–72. doi: 10.1016/S0925-4773(98)00174-9 . PMID   10349621. S2CID   6057216.
• Liang Y, Annan RS, Carr SA, et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–92. doi: 10.1074/jbc.274.25.17885 . PMID   10364234.
• Wu W, Wong K, Chen J, et al. (1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature. 400 (6742): 331–6. Bibcode:1999Natur.400..331W. doi:10.1038/22477. PMC   2041931 . PMID   10432110.
• Georgas K, Burridge L, Smith K, et al. (2000). "Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2". Cytogenet. Cell Genet. 86 (3–4): 246–7. doi:10.1159/000015351. PMID   10575218. S2CID   6028258.
• Niclou SP, Jia L, Raper JA (2000). "Slit2 is a repellent for retinal ganglion cell axons". J. Neurosci. 20 (13): 4962–74. doi:10.1523/JNEUROSCI.20-13-04962.2000. PMC   6772294 . PMID   10864954.
• Zou Y, Stoeckli E, Chen H, Tessier-Lavigne M (2000). "Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord" (PDF). Cell. 102 (3): 363–75. doi:10.1016/S0092-8674(00)00041-6. PMID   10975526. S2CID   14174593. Archived from the original (PDF) on 2018-11-01. Retrieved 2020-09-11.
• Chen JH, Wen L, Dupuis S, et al. (2001). "The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons". J. Neurosci. 21 (5): 1548–56. doi: 10.1523/JNEUROSCI.21-05-01548.2001 . PMC   6762944 . PMID   11222645.
• Wu JY, Feng L, Park HT, et al. (2001). "The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors". Nature. 410 (6831): 948–52. Bibcode:2001Natur.410..948W. doi:10.1038/35073616. PMC   2072862 . PMID   11309622.
• Ronca F, Andersen JS, Paech V, Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31): 29141–7. doi: 10.1074/jbc.M100240200 . PMID   11375980.
• Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". J. Neurosci. 21 (12): 4281–9. doi: 10.1523/JNEUROSCI.21-12-04281.2001 . PMC   6762758 . PMID   11404413.
• Little M, Rumballe B, Georgas K, et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. 46 (4): 385–91. PMID   12141424.
• Dallol A, Da Silva NF, Viacava P, et al. (2002). "SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers". Cancer Res. 62 (20): 5874–80. PMID   12384551.