SLITRK2

SLITRK2
Identifiers
Aliases	SLITRK2 , CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDs	OMIM: 300561; MGI: 2679449; HomoloGene: 13054; GeneCards: SLITRK2; OMA:SLITRK2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq27.3 Start 145,817,829 bp [1] End 145,829,856 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A7.1 Start 65,692,924 bp [2] End 65,704,999 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone internal globus pallidus caudate nucleus nucleus accumbens ganglionic eminence middle temporal gyrus amygdala right frontal lobe putamen C1 segment Top expressed in trigeminal ganglion substantia nigra lumbar subsegment of spinal cord Region I of hippocampus proper dentate gyrus dentate gyrus of hippocampal formation granule cell subiculum ventricular zone neural layer of retina primary motor cortex More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 84631 245450 Ensembl ENSG00000185985 ENSMUSG00000036790 UniProt Q9H156 Q810C0 RefSeq (mRNA) NM_001144003 NM_001144004 NM_001144005 NM_001144006 NM_001144007 NM_001144008 NM_001144009 NM_001144010 NM_032539 NM_001161431 NM_198863 RefSeq (protein) NP_001137475 NP_001137476 NP_001137477 NP_001137478 NP_001137480 NP_001137481 NP_001137482 NP_115928 NP_001154903 NP_942563 Location (UCSC) Chr X: 145.82 – 145.83 Mb Chr X: 65.69 – 65.7 Mb PubMed search [3] [4]
Wikidata
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SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene. ^{[5] [6] [7]}

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity. ^{[7] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000185985 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036790 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
6. Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID   14557068.
7. "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.