SLITRK2

Last updated
SLITRK2
Identifiers
Aliases SLITRK2 , CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDs OMIM: 300561 MGI: 2679449 HomoloGene: 13054 GeneCards: SLITRK2
Gene location (Human)
Ideogram human chromosome X.svg
Chr. X chromosome (human) [1]
Human chromosome X ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band Xq27.3Start145,817,832 bp [1]
End145,829,856 bp [1]
RNA expression pattern
PBB GE SLITRK2 gnf1h04933 at fs.png

PBB GE SLITRK2 gnf1h11398 at fs.png

PBB GE SLITRK2 gnf1h04919 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161431
NM_198863

RefSeq (protein)

NP_001154903
NP_942563

Location (UCSC) Chr X: 145.82 – 145.83 Mb Chr X: 66.65 – 66.66 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene. [5] [6] [7]

Contents

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity. [7] [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185985 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036790 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
  6. 1 2 Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID   14557068.
  7. 1 2 "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Further reading