SMG5

SMG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HWY
Identifiers
Aliases	SMG5 , EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962 MGI: 2447364 HomoloGene: 9095 GeneCards: SMG5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,282,825 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,269,645 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; anterior pituitary; ; Right adrenal gland; ; skin of abdomen; ; left ventricle; ; right lobe of liver; ; upper lobe of left lung; ; body of stomach; ; tibial nerve; ; right lung;
	Top expressed in
	spermatocyte; ; spermatid; ; superior frontal gyrus; ; lip; ; seminiferous tubule; ; cerebellar cortex; ; yolk sac; ; thymus; ; lacrimal gland; ; esophagus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding ; histone deacetylase binding ; protein binding ; telomeric DNA binding ; ubiquitin protein ligase binding ; ribonuclease activity ; ribonucleoprotein complex binding ; telomerase RNA binding ;
Cellular component	cytoplasm ; cytosol ; nucleus ; telomerase holoenzyme complex ;
Biological process	regulation of dephosphorylation ; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ; mRNA export from nucleus ; regulation of telomere maintenance ; regulation of telomere maintenance via telomerase ; regulation of RNA stability ; RNA phosphodiester bond hydrolysis ; telomere maintenance via telomerase ;
	Sources:Amigo / QuickGO
Orthologs
	23381
	229512
	ENSG00000198952
	ENSMUSG00000001415
	Q9UPR3
	Q6ZPY2
	NM_015327 ; NM_001323614 ; NM_001323615 ; NM_001323616 ; NM_001323617
	NM_173188 ; NM_178246
	NP_001310543 ; NP_001310544 ; NP_001310545 ; NP_001310546 ; NP_056142
	NP_839977
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.^[5]^[6]^[7] This protein contains a PIN domain that appears to have mutated the residues in the active site.^[8]

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Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure for this domain has been determined by X-ray crystallography. SMG6 functions to bind single-stranded DNA in telomere maintenance and single-stranded RNA in nonsense-mediated mRNA decay (NMD). The SMG6 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198952 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001415 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi: 10.1016/S0960-9822(03)00173-8 . PMID 12676087. S2CID 14423276.
↑ Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi: 10.1016/S0960-9822(03)00210-0 . PMID 12699629. S2CID 6685276.
↑ "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
↑ Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413 . PMID 17053788.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. doi: 10.1016/S1097-2765(03)00443-X . PMID 14636577.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Unterholzner L, Izaurralde E (2005). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Mol. Cell. 16 (4): 587–96. doi: 10.1016/j.molcel.2004.10.013 . PMID 15546618.
Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Mol. Cell. 17 (4): 537–47. doi: 10.1016/j.molcel.2005.01.010 . PMID 15721257.
Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. doi: 10.1016/j.cub.2006.01.018 . PMID 16488880. S2CID 17197870.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Lee H, Sengupta N, Villagra A, et al. (2006). "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation". Mol. Cell. Biol. 26 (14): 5259–69. doi:10.1128/MCB.01971-05. PMC 1592721 . PMID 16809764.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198952 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001415 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12676087-5] Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi: 10.1016/S0960-9822(03)00173-8 . PMID 12676087. S2CID 14423276.

[pmid12699629-6] Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi: 10.1016/S0960-9822(03)00210-0 . PMID 12699629. S2CID 6685276.

[entrez-7] "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".

[pmid17053788-8] Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413 . PMID 17053788.

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SMG5

Related Research Articles

References

Further reading