SMG5

SMG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HWY
Identifiers
Aliases	SMG5 , EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDs	OMIM: 610962; MGI: 2447364; HomoloGene: 9095; GeneCards: SMG5; OMA:SMG5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 156,249,224 bp [1] End 156,282,825 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,243,567 bp [2] End 88,269,645 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle anterior pituitary right adrenal gland granulocyte right hemisphere of cerebellum C1 segment right adrenal cortex left adrenal cortex skin of leg Top expressed in spermatocyte spermatid superior frontal gyrus neural layer of retina ventricular zone lip muscle of thigh seminiferous tubule dentate gyrus of hippocampal formation granule cell tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 2A binding histone deacetylase binding protein binding telomeric DNA binding ubiquitin protein ligase binding ribonuclease activity ribonucleoprotein complex binding telomerase RNA binding Cellular component cytoplasm cytosol nucleus telomerase holoenzyme complex Biological process regulation of dephosphorylation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA export from nucleus regulation of telomere maintenance regulation of telomere maintenance via telomerase regulation of RNA stability RNA phosphodiester bond hydrolysis telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23381 229512 Ensembl ENSG00000198952 ENSMUSG00000001415 UniProt Q9UPR3 Q6ZPY2 RefSeq (mRNA) NM_015327 NM_001323614 NM_001323615 NM_001323616 NM_001323617 NM_173188 NM_178246 RefSeq (protein) NP_001310543 NP_001310544 NP_001310545 NP_001310546 NP_056142 NP_839977 Location (UCSC) Chr 1: 156.25 – 156.28 Mb Chr 3: 88.24 – 88.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene. ^{[5] [6] [7]} This protein contains a PIN domain that appears to have mutated the residues in the active site. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000198952 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001415 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi: 10.1016/S0960-9822(03)00173-8 . PMID   12676087. S2CID   14423276.
6. Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi: 10.1016/S0960-9822(03)00210-0 . PMID   12699629. S2CID   6685276.
7. "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
8. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC   1630413 . PMID   17053788.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID   10470851.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ohnishi T, Yamashita A, Kashima I, et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. doi: 10.1016/S1097-2765(03)00443-X . PMID   14636577.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Unterholzner L, Izaurralde E (2005). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Mol. Cell. 16 (4): 587–96. doi: 10.1016/j.molcel.2004.10.013 . PMID   15546618.
• Fukuhara N, Ebert J, Unterholzner L, et al. (2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Mol. Cell. 17 (4): 537–47. doi: 10.1016/j.molcel.2005.01.010 . PMID   15721257.
• Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. doi: 10.1016/j.cub.2006.01.018 . PMID   16488880. S2CID   17197870.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Lee H, Sengupta N, Villagra A, et al. (2006). "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation". Mol. Cell. Biol. 26 (14): 5259–69. doi:10.1128/MCB.01971-05. PMC   1592721 . PMID   16809764.