SMIM20 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SMIM20 , C4orf52, small integral membrane protein 20, MITRAC7, PNX | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 617465 MGI: 1913528 HomoloGene: 82612 GeneCards: SMIM20 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Small integral membrane protein (SMIM) 20 is a protein that in humans is encoded by the SMIM20 gene. [5] SMIM20 acts as a prohormone to the peptide hormone phoenixin which was discovered for the first time in 2013 in rodent sensory ganglia. [6]
In the study of the evolution of nervous systems, SMIM20 together with NUCB2 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates. [7] [8]
Retinal guanylyl cyclase 1 also known as guanylate cyclase 2D, retinal is an enzyme that in humans is encoded by the GUCY2D gene.
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.
Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme that in humans is encoded by the MBTPS1 gene. S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors.
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.
Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene. GPR19 has been proposed as the receptor for the peptide hormone adropin.
Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.
Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.
Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.
Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene. The GPC2 gene is at locus 7q22.1 and encodes for a 579 amino acid protein. The C-terminus of GPC2 has the GPI attachment site, at G554, and the N-terminus encodes a signal peptide, from M1 to S24. Multiple GPC2 mRNA transcripts have been identified. GPC2-201 is the isoform overexpressed in pediatric cancers. Tumor-associated exon 3 of GPC2 shows the lowest expression in normal tissues compared with other exons.
Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.
Anterior gradient protein 3 homolog is a protein that in humans is encoded by the AGR3 gene.
T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.
Membrane progesterone receptor beta (mPRβ), or progestin and adipoQ receptor 8 (PAQR8), is a protein that in humans is encoded by the PAQR8 gene.
CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene.
Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.
Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 gene. It was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes.
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.
Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS. The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.
Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.
LanC like 1 is a protein that in humans is encoded by the LANCL1 gene.