Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene. [5] [6] [7] [8]
Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene. [5] [6] [7] [8]
The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Amphiphysin is a protein that in humans is encoded by the AMPH gene.
Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene.
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.
AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene.
Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.
Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.
AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene.
Epsin-1 is a protein that in humans is encoded by the EPN1 gene.
Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.
Epsin-2 is a protein that in humans is encoded by the EPN2 gene.
AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.
SacI homology domain is a family of evolutionarily related proteins.
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. The association between adaptins and clathrin are important for vesicular cargo selection and transporting. Clathrin coats contain both clathrin and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and the monomeric GGA adaptors. Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between 16% and 26% of their amino acid sequence.
The C-terminal domain ofBeta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell.
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