SND1

Last updated
SND1
Protein SND1 PDB 2hqx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SND1 , TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
External IDs OMIM: 602181 MGI: 1929266 HomoloGene: 8665 GeneCards: SND1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014390

NM_019776

RefSeq (protein)

NP_055205

NP_062750

Location (UCSC) Chr 7: 127.65 – 128.09 Mb Chr 6: 28.48 – 28.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. [5] [6] [7] [8] SND1 is a main component of RISC complex [9] and plays an important role in miRNA function. [10] [11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. [12] SND1 is also involved in Autism. [13]

Contents

Clinical significance

SND1 acts as oncogene in many cancers [14] [15] [16] and in hepatocellular carcinoma progression. [10] [11] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221. [17] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling. [18] SND1 expression is regulated by Mir-184 in gliomas. [19]

Interactions

SND1 has been shown to interact with MYB, [20]

SND1 also interacts with G3BP (stress granule protein) [25] and AEG-1. [10] [11]

Related Research Articles

Gene knockdown is an experimental technique by which the expression of one or more of an organism's genes is reduced. The reduction can occur either through genetic modification or by treatment with a reagent such as a short DNA or RNA oligonucleotide that has a sequence complementary to either gene or an mRNA transcript.

The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety of pathways at the transcriptional and translational levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as a key tool in gene regulation. The single strand of RNA acts as a template for RISC to recognize complementary messenger RNA (mRNA) transcript. Once found, one of the proteins in RISC, Argonaute, activates and cleaves the mRNA. This process is called RNA interference (RNAi) and it is found in many eukaryotes; it is a key process in defense against viral infections, as it is triggered by the presence of double-stranded RNA (dsRNA).

<span class="mw-page-title-main">Micrococcal nuclease</span> Class of enzymes

Micrococcal nuclease is an endo-exonuclease that preferentially digests single-stranded nucleic acids. The rate of cleavage is 30 times greater at the 5' side of A or T than at G or C and results in the production of mononucleotides and oligonucleotides with terminal 3'-phosphates. The enzyme is also active against double-stranded DNA and RNA and all sequences will be ultimately cleaved.

<span class="mw-page-title-main">EP300</span> Protein-coding gene in the species Homo sapiens

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

p300-CBP coactivator family Protein family

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins :

  1. p300
  2. CBP
<span class="mw-page-title-main">POLR2A</span> Protein-coding gene in the species Homo sapiens

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the POLR2A gene.

<span class="mw-page-title-main">MYB (gene)</span> Protein-coding gene in the species Homo sapiens

Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains.

<span class="mw-page-title-main">MYBL2</span> Protein-coding gene in the species Homo sapiens

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

<span class="mw-page-title-main">DDX5</span> Protein-coding gene in Homo sapiens

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

<span class="mw-page-title-main">SRA1</span> Protein-coding gene in the species Homo sapiens

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.

<span class="mw-page-title-main">G3BP1</span> Protein-coding gene in the species Homo sapiens

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

<span class="mw-page-title-main">POU2AF1</span>

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. The protein is also termed Oct coactivator from B cells, Oct binding factor 1, and, as commonly found in the literature, BOB1. BOB1 is a transcriptional coactivator which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36. The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas, as exemplified in studies which use BAB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.

<span class="mw-page-title-main">TFCP2</span> Protein-coding gene in the species Homo sapiens

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.

<span class="mw-page-title-main">SPIB</span> Protein that controls transcription of a set of genes in eukaryotes

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.

<span class="mw-page-title-main">CRTC2</span> Protein-coding gene in the species Homo sapiens

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.

<span class="mw-page-title-main">MTDH</span> Protein-coding gene in the species Homo sapiens

Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.

<span class="mw-page-title-main">Tudor domain</span>

In molecular biology, a Tudor domain is a conserved protein structural domain originally identified in the Tudor protein encoded in Drosophila. The Tudor gene was found in a Drosophila screen for maternal factors that regulate embryonic development or fertility. Mutations here are lethal for offspring, inspiring the name Tudor, as a reference to the Tudor King Henry VIII and the several miscarriages experienced by his wives.

mir-221 microRNA

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology, the BESS domain is a protein domain which has been named after the three proteins that originally defined the domain: BEAF, Suvar(3)7 and Stonewall ). The BESS domain is 40 amino acid residues long and is predicted to be composed of three alpha helices, as such it might be related to the myb/SANT HTH domain. The BESS domain directs a variety of protein-protein interactions, including interactions with itself, with Dorsal, and with a TBP-associated factor. It is found in a single copy in Drosophila proteins and is often associated with the MADF domain.

<span class="mw-page-title-main">KIX domain</span>

In biochemistry, the KIX domain (kinase-inducible domain (KID) interacting domain) or CREB binding domain is a protein domain of the eukaryotic transcriptional coactivators CBP and P300. It serves as a docking site for the formation of heterodimers between the coactivator and specific transcription factors. Structurally, the KIX domain is a globular domain consisting of three α-helices and two short 310-helices.

References

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Further reading