SPDEF

Last updated
SPDEF
Protein SPDEF PDB 1yo5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SPDEF , PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
External IDs OMIM: 608144 MGI: 1353422 HomoloGene: 8231 GeneCards: SPDEF
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252294
NM_012391

NM_013891
NM_001357728

RefSeq (protein)

NP_001239223
NP_036523

NP_038919
NP_001344657

Location (UCSC) Chr 6: 34.54 – 34.56 Mb Chr 17: 27.93 – 27.95 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. [5] [6] [7]

Contents

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM] [7]

Interactions

SPDEF has been shown to interact with NKX3-1. [8]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124664 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024215 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, et al. (January 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". The Journal of Biological Chemistry. 275 (2): 1216–1225. doi: 10.1074/jbc.275.2.1216 . PMID   10625666.
  6. Johannessen JV, Finseth I (January 1983). "Electron micrographs in five minutes". Ultrastructural Pathology. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID   6857767.
  7. 1 2 "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
  8. Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID   11809674.

Further reading