SPN1

SNUPN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XK5, 2P8Q, 2Q5D, 2QNA, 3GB8, 3GJX, 3LWW, 3NBY, 3NBZ, 3NC0
Identifiers
Aliases	SNUPN , KPNBL, RNUT1, Snurportin1, snurportin 1
External IDs	OMIM: 607902; MGI: 1913319; HomoloGene: 4166; GeneCards: SNUPN; OMA:SNUPN - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.2 Start 75,598,083 bp [1] End 75,626,469 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 56,858,162 bp [2] End 56,890,490 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis smooth muscle tissue skeletal muscle tissue muscle of thigh gonad gastrocnemius muscle right ovary left ovary fallopian tube Top expressed in otolith organ utricle primary oocyte zygote superior cervical ganglion hand morula interventricular septum secondary oocyte seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA cap binding RNA binding protein binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore nucleus intracellular anatomical structure Biological process snRNA import into nucleus protein import into nucleus spliceosomal snRNP assembly import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10073 66069 Ensembl ENSG00000169371 ENSMUSG00000055334 UniProt O95149 Q80W37 RefSeq (mRNA) NM_005701 NM_001042581 NM_001042588 NM_178374 RefSeq (protein) NP_001036046 NP_001036053 NP_005692 NP_848461 Location (UCSC) Chr 15: 75.6 – 75.63 Mb Chr 9: 56.86 – 56.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Snurportin1 is a protein that in humans is encoded by the SNUPN gene. ^{[5] [6]}

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5 is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169371 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055334 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (Sep 1998). "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure". EMBO J. 17 (14): 4114–26. doi:10.1093/emboj/17.14.4114. PMC   1170744 . PMID   9670026.
6. "Entrez Gene: SNUPN snurportin 1".

Further reading

• Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm". J. Cell Biol. 145 (2): 255–64. doi:10.1083/jcb.145.2.255. PMC   2133107 . PMID   10209022.
• Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta". Hum. Mol. Genet. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC   1630493 . PMID   12095920.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strasser A, Dickmanns A, Lührmann R, Ficner R (2005). "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1". EMBO J. 24 (13): 2235–43. doi:10.1038/sj.emboj.7600701. PMC   1173142 . PMID   15920472.
• Ospina JK, Gonsalvez GB, Bednenko J, et al. (2006). "Cross-talk between snurportin1 subdomains". Mol. Biol. Cell. 16 (10): 4660–71. doi:10.1091/mbc.E05-04-0316. PMC   1237072 . PMID   16030253.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.

External links

• SNUPN human gene location in the UCSC Genome Browser .
• SNUPN human gene details in the UCSC Genome Browser .