SPOP

SPOP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CR2, 3HQH, 3HQI, 3HQL, 3HQM, 3HTM, 3HU6, 3IVB, 3IVQ, 3IVV, 4EOZ, 4HS2, 4J8Z, 4O1V Contents Clinical relevance ; References ; Further reading ;
Identifiers
Aliases	SPOP , BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
External IDs	OMIM: 602650 MGI: 1343085 HomoloGene: 68354 GeneCards: SPOP
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,678,163 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,384,232 bp
RNA expression pattern
	Top expressed in
	nipple; ; saphenous vein; ; pylorus; ; seminal vesicula; ; popliteal artery; ; urethra; ; cardia; ; smooth muscle tissue; ; ascending aorta; ; lower lobe of lung;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; cerebellar vermis; ; ankle; ; sternocleidomastoid muscle; ; digastric muscle; ; parotid gland; ; blood; ; lacrimal gland; ; body of femur;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; ubiquitin protein ligase binding ;
Cellular component	Cul3-RING ubiquitin ligase complex ; nuclear speck ; nucleus ; nucleoplasm ; cytoplasm ; SCF ubiquitin ligase complex ;
Biological process	protein ubiquitination ; regulation of proteolysis ; negative regulation of transcription by RNA polymerase II ; glucose homeostasis ; proteasome-mediated ubiquitin-dependent protein catabolic process ; negative regulation of DNA-binding transcription factor activity ; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ; positive regulation of type B pancreatic cell apoptotic process ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	8405
	20747
	ENSG00000121067
	ENSMUSG00000057522
	O43791
	Q6ZWS8
NM_001007226 ; NM_001007227 ; NM_001007228 ; NM_001007229 ; NM_001007230 ;
	NM_003563 ; NM_001370730 ; NM_001370731 ; NM_001370732
	NM_025287 ; NM_001359107
NP_001007227 ; NP_001007228 ; NP_001007229 ; NP_001007230 ; NP_001007231 ;
	NP_003554 ; NP_001357659 ; NP_001357660 ; NP_001357661
	NP_079563 ; NP_001346036
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.^[5]^[6]^[7]

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.^[7]

Clinical relevance

Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers.^[8]^[9]

Related Research Articles

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5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ direction.

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Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene.

Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a, is a histone methyltransferase enzyme that in humans is encoded by the EHMT2 gene. G9a catalyzes the mono- and di-methylated states of histone H3 at lysine residue 9 and lysine residue 27.

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

Tripartite motif-containing protein 37 is an E3 ubiquitin ligase in humans that is encoded by the TRIM37 gene.

NKG2-C type II integral membrane protein or NKG2C is a protein that in humans is encoded by the KLRC2 gene. It is also known as or cluster of differentiation 159c (CD159c).

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.

The Chromodomain-Helicase DNA-binding 1 is a protein that, in humans, is encoded by the CHD1 gene. CHD1 is a chromatin remodeling protein that is widely conserved across many eukaryotic organisms, from yeast to humans. CHD1 is named for three of its protein domains: two tandem chromodomains, its ATPase catalytic domain, and its DNA-binding domain.

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.

SET and MYND (myeloid-Nervy-DEAF-1) domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121067 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057522 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M (Nov 1997). "Identification of a novel nuclear speckle-type protein, SPOP". FEBS Letters. 418 (1–2): 23–6. doi: 10.1016/S0014-5793(97)01340-9 . PMID 9414087. S2CID 32204506.
↑ Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi: 10.1074/jbc.M100354200 . PMID 11279055.
1 2 "Entrez Gene: SPOP speckle-type POZ protein".
↑ Heidi Evans (20 May 2012). "Scientists find new type of prostate cancer - discovery may lead to tailored treatments". New York Daily News. Retrieved 20 May 2012.
↑ Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022 . PMID 22610119.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH (Jul 1999). "An activating immunoreceptor complex formed by NKG2D and DAP10". Science. 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi: 10.1074/jbc.M100354200 . PMID 11279055.
Takahashi I, Kameoka Y, Hashimoto K (Aug 2002). "MacroH2A1.2 binds the nuclear protein Spop". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1591 (1–3): 63–8. doi: 10.1016/S0167-4889(02)00249-5 . PMID 12183056.
Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M (Dec 2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nature Immunology. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH (Dec 2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nature Immunology. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ (Jun 2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nature Immunology. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
Liu A, Desai BM, Stoffers DA (May 2004). "Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity". Molecular and Cellular Biology. 24 (10): 4372–83. doi:10.1128/MCB.24.10.4372-4383.2004. PMC 400448 . PMID 15121856.
La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO (Jul 2004). "Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP". Biochemical and Biophysical Research Communications. 320 (3): 760–5. doi:10.1016/j.bbrc.2004.06.022. PMID 15240113.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7635–40. doi: 10.1073/pnas.0408918102 . PMC 1140410 . PMID 15897469.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000121067 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057522 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9414087-5] Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M (Nov 1997). "Identification of a novel nuclear speckle-type protein, SPOP". FEBS Letters. 418 (1–2): 23–6. doi: 10.1016/S0014-5793(97)01340-9 . PMID 9414087. S2CID 32204506.

[pmid11279055-6] Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC (Jun 2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". The Journal of Biological Chemistry. 276 (26): 24242–52. doi: 10.1074/jbc.M100354200 . PMID 11279055.

[entrez-7] 1 2 "Entrez Gene: SPOP speckle-type POZ protein".

[NYDNHeidiEvans-8] Heidi Evans (20 May 2012). "Scientists find new type of prostate cancer - discovery may lead to tailored treatments". New York Daily News. Retrieved 20 May 2012.

[doi.10.1038/ng.2279-9] Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022 . PMID 22610119.

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SPOP

Contents

Clinical relevance

Related Research Articles

References

Further reading