SRT-3025

Last updated
SRT-3025
SRT3025 structure.png
Identifiers
  • 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(pyrrolidin-1-ylmethyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]-1,3-thiazole-4-carboxamide
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C31H31N5O2S2
Molar mass 569.74 g·mol−1
3D model (JSmol)
  • COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6
  • InChI=1S/C31H31N5O2S2/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37)
  • Key:MRRXPMZNBRXCPZ-UHFFFAOYSA-N

SRT-3025 is an experimental drug that was studied by Sirtris Pharmaceuticals as a small-molecule activator of the sirtuin subtype SIRT1. It has been investigated as a potential treatment for osteoporosis, [1] [2] [3] [4] [5] and anemia. [6] [7]

See also

References

  1. ↑ Li Y, Shen G, Yu C, Li G, Shen J, Gong J, Xu Y (December 2014). "Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway". Biochemical and Biophysical Research Communications. 455 (1–2): 113–8. doi:10.1016/j.bbrc.2014.10.123. PMID   25450701.
  2. ↑ Gurt I, Artsi H, Cohen-Kfir E, Hamdani G, Ben-Shalom G, Feinstein B, et al. (2015). "The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells". PLOS ONE. 10 (7) e0134391. Bibcode:2015PLoSO..1034391G. doi: 10.1371/journal.pone.0134391 . PMC   4520518 . PMID   26226624.
  3. ↑ Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, et al. (October 2015). "Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs". Molecular Endocrinology. 29 (10): 1498–509. doi:10.1210/me.2015-1133. PMC   4588729 . PMID   26287518.
  4. ↑ Zainabadi K (May 2019). "Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?". Pharmacological Research. 143: 97–105. doi:10.1016/j.phrs.2019.03.007. PMID   30862606. S2CID   76663834.
  5. ↑ Artsi H, Gurt I, El-Haj M, Müller R, Kuhn GA, Ben Shalom G, et al. (2019). "Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men". Frontiers in Endocrinology. 10: 126. doi: 10.3389/fendo.2019.00126 . PMC   6403178 . PMID   30873124.
  6. ↑ Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M (July 2015). "The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice". Stem Cell Research. 15 (1): 130–40. doi:10.1016/j.scr.2015.05.007. PMC   4516677 . PMID   26046330.
  7. ↑ Lin X, Liu C, Wang T, Wang H, Shao Z (2019). "Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia". Acta Haematologica. 142 (3): 142–148. doi:10.1159/000497404. PMID   31141802. S2CID   169038775.


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