SSBP1

Last updated
SSBP1
Protein SSBP1 PDB 1s3o.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SSBP1 , Mt-SSB, SOSS-B1, SSBP, mtSSB, single stranded DNA binding protein 1, OPA13
External IDs OMIM: 600439 MGI: 1920040 HomoloGene: 74462 GeneCards: SSBP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256510
NM_001256511
NM_001256512
NM_001256513
NM_003143

Contents

NM_001286663
NM_028358
NM_212468
NM_001364578

RefSeq (protein)

NP_001243439
NP_001243440
NP_001243441
NP_001243442
NP_003134

NP_001273592
NP_082634
NP_997633
NP_001351507

Location (UCSC) Chr 7: 141.74 – 141.79 Mb Chr 6: 40.45 – 40.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene. [5] [6]

Function

SSBP 1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995).[supplied by OMIM] [6]

See also

Related Research Articles

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Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

<span class="mw-page-title-main">POLG</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TFAM</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Twinkle (protein)</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">Paraplegin</span> Protein-coding gene in the species Homo sapiens

Paraplegin is a protein that in humans is encoded by the SPG7 gene located on chromosome 16.

<span class="mw-page-title-main">ETHE1</span> Protein-coding gene in the species Homo sapiens

Protein ETHE1, mitochondrial, also known as "ethylmalonic encephalopathy 1 protein" and "per sulfide dioxygenase", is a protein that in humans is encoded by the ETHE1 gene located on chromosome 19.

<span class="mw-page-title-main">MPV17</span> Protein-coding gene in the species Homo sapiens

Protein MPV17 is a protein that in humans is encoded by the MPV17 gene. It is a mitochondrial inner membrane protein, which has a so far largely unknown role in mtDNA maintenance. Protein MPV17 is expressed in human pancreas, kidney, muscle, liver, lung, placenta, brain and heart. Human MPV17 is the orthologue of the mouse kidney disease gene, Mpv17. Loss of function has been shown to cause hepatocerebral mtDNA depletion syndromes (MDS) with oxidative phosphorylation failure and mtDNA depletion both in affected individuals and in Mpv17−/− mice.

<span class="mw-page-title-main">Mitochondrial 2-oxoglutarate/malate carrier protein</span> Mammalian protein found in Homo sapiens

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene. Inactivating mutations in this gene predispose to metastasic paraganglioma.

<span class="mw-page-title-main">SSBP2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">MRPS22</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.

<span class="mw-page-title-main">ENDOG</span> Protein-coding gene in the species Homo sapiens

Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress. As a result, EndoG has been implicated in cancer, aging, and neurodegenerative diseases such as Parkinson’s disease (PD). Regulation of its expression levels thus holds potential to treat or ameliorate those conditions.

<span class="mw-page-title-main">POLRMT</span> Protein-coding gene in the species Homo sapiens

POLRMT is a symbol of RNA polymerase mitochondrial

<span class="mw-page-title-main">RBMS1</span> Protein-coding gene in the species Homo sapiens

RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.

<span class="mw-page-title-main">PUS1</span> Protein-coding gene in the species Homo sapiens

tRNA pseudouridine synthase A is an enzyme that in humans is encoded by the PUS1 gene.

<span class="mw-page-title-main">SSBP3</span> Protein-coding gene in the species Homo sapiens

Single-stranded DNA-binding protein 3 is a protein that in humans is encoded by the SSBP3 gene.

<span class="mw-page-title-main">ADP/ATP translocase 3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Single-stranded binding protein</span>

Single-stranded binding proteins (SSBs) are a class of proteins that have been identified in both viruses and organisms from bacteria to humans.

<span class="mw-page-title-main">PET100</span> Protein-coding gene in the species Homo sapiens

PET100 homolog is a protein that in humans is encoded by the PET100 gene. Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by the PET100 gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants.

<span class="mw-page-title-main">PET117</span> Protein-coding gene in the species Homo sapiens

PET117 homolog is a protein that in humans is encoded by the PET117 gene. Localized to mitochondria, this protein is a chaperone protein involved in the assembly of mitochondrial Complex IV, or Cytochrome C Oxidase. Mutations in this gene can cause Complex IV deficiency with symptoms including medulla oblongata lesions and lactic acidosis.

<span class="mw-page-title-main">SSBP4</span> Protein-coding gene in the species Homo sapiens

Single-stranded DNA-binding protein 4 is a protein that in humans is encoded by the SSBP4 gene.

References

  1. 1 2 3 ENSG00000106028 GRCh38: Ensembl release 89: ENSG00000262771, ENSG00000106028 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029911 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (January 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID   7789991.
  6. 1 2 "Entrez Gene: SSBP1 single-stranded DNA binding protein 1".

Further reading